Tp5, a peptide inhibitor of aberrant and hyperactive cdk5/p25 as treatment for cancer
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsZhengping Zhuang, Emeline Tabouret, Herui Wang, Harish Pant, Niranjana D. Amin
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Abstract
Methods of decreasing cell viability of cancer cells, increasing apoptosis of cancer cells, and treating cancer in a mammal with cancer are provided. The methods include administering (i) a polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 1, (ii) a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide, (iii) a vector comprising the nucleic acid molecule, (iv) a recombinant cell comprising any one of (i)-(iii), and/or (v) a composition comprising any one of (i)-(iv).
Claims14
A method of decreasing cell viability of cancer cells comprising administering to the cancer cells one or more of the following:
- (i) a polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 1,
- (ii) a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide,
- (iii) a vector comprising the nucleic acid molecule, and
- (iv) a composition comprising any one of (i)-(iii).
A method of increasing apoptosis of cancer cells comprising administering to the cancer cells one or more of the following:
- (i) a polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 1,
- (ii) a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide, and
- (iii) a vector comprising the nucleic acid molecule, and
- (iv) a composition comprising any one of (i)-(iii).
A method of treating cancer in a mammal with cancer comprising administering to the mammal one or more of the following:
- (i) a polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 1,
- (ii) a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide,
- (iii) a vector comprising the nucleic acid molecule,
- (iv) a recombinant cell comprising any one of (i)-(iii), and
- (v) a composition comprising any one of (i)-(iv).
A (i) polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 1, (ii) nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide, (iii) vector comprising the nucleic acid molecule, or (iv) a composition comprising any one of (i)-(iii) for use in decreasing cell viability of cancer cells and/or increasing apoptosis of cancer cells.
A (i) polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 1, (ii) nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide, (iii) vector comprising the nucleic acid molecule, or (iv) a composition comprising any one of (i)-(iii) for use in treating cancer in a mammal with cancer.
Dependencies are inferred from the claim text.