Peptide Possessing Mesenchymal-Stem-Cell Mobilizing Activity
AssigneesStemrim Inc., Osaka University
InventorsKatsuto TAMAI, Takashi SHIMBO, Takehiko YAMAZAKI, Koichi YOKOTA
Life of this patent
Estimating the term…
Abstract
The present inventors designed an artificial sequence peptide based on the results of original research conducted so far, and found that the peptide exhibits an activity of mobilizing mesenchymal stem cells into peripheral blood. The present inventors also found that the artificial sequence peptide has a therapeutic effect on inflammatory bowel disease, atopic dermatitis, and cerebral infarction. Based on these findings, a new regenerative medicine technology that can overcome the problems of cell transplantation therapy is provided.
Claims10
A method for mobilizing mesenchymal stem cells to peripheral blood, comprising administering to a subject an effective amount of a peptide selected from the following:
- (a) a peptide comprising the amino acid sequence of SEQ ID NO:
- 1;
- (b) a peptide comprising an amino acid sequence resulting from substitution, deletion, insertion, or addition of one or several amino acids in the amino acid sequence of SEQ ID NO:
- 1;
- and
- (c) a peptide comprising an amino acid sequence with a sequence identity of about 90°/a or higher with the amino acid sequence of SEQ ID NO:
- 1.
A method for treating a disease or pathological condition in a subject by mobilizing mesenchymal stem cells to peripheral blood, which comprises administering to the subject an effective amount of a peptide selected from the following:
- (a) a peptide comprising the amino acid sequence of SEQ ID NO:
- 1;
- (b) a peptide comprising an amino acid sequence resulting from substitution, deletion, insertion, or addition of one or several amino acids in the amino acid sequence of SEQ ID NO:
- 1;
- and
- (c) a peptide comprising an amino acid sequence with a sequence identity of about 90% or higher with the amino acid sequence of SEQ ID NO:
- 1.
A method for treating a disease selected from inflammatory bowel disease, atopic dermatitis, and cerebral infarction in a subject, which comprises administering to the subject an effective amount of a peptide selected from the following:
- (a) a peptide comprising the amino acid sequence of SEQ ID NO:
- 1;
- (b) a peptide comprising an amino acid sequence resulting from substitution, deletion, insertion, or addition of one or several amino acids in the amino acid sequence of SEQ ID NO:
- 1;
- and
- (c) a peptide comprising an amino acid sequence with a sequence identity of about 90% or higher with the amino acid sequence of SEQ ID NO:
- 1.
A peptide selected from the following:
- (a) a peptide comprising the amino acid sequence of SEQ ID NO:
- 1;
- (b) a peptide comprising an amino acid sequence resulting from substitution, deletion, insertion, or addition of one or several amino acids in the amino acid sequence of SEQ ID NO:
- 1;
- and
- (c) a peptide comprising an amino acid sequence with a sequence identity of about 90% or higher with the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.