Novel urea 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazines active against the hepatitis b virus (hbv)

A compound of Formula I

• in which
• R1 is phenyl or pyridyl, optionally substituted once, twice or thrice with H, CF2H, CF3, CF2CH3, F, Cl, Br, CH3, Et, i-Pr, c-Pr, D, CH2OH, CH(CH3)OH, CH2F, CH(F)CH3, I, C═C, C≡C, C≡N, C(CH3)2OH, SCH3, OH, or OCH3
• R2 is H or methyl
• R3 is selected from the group comprising H, D, SO2—C1-C6-alkyl, SO2—C3-C7-cycloalkyl, SO2—C3-C7-heterocycloalkyl, SO2—C2-C6-hydroxyalkyl, SO2—C2-C6-alkyl-O—C1-C6-alkyl, SO2—C1-C4-carboxyalkyl, SO2-aryl, SO2-heteroaryl, SO2—N(R12)(R13), C(═O)R5, C(═O)N(R12)(R13), C(═O)C(═O)N(R12)(R13), C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-alkyl-O—C1-C6-alkyl, C1-C4-carboxyalkyl, C1-C4-acylsulfonamido-alkyl, C1-C4-carboxamidoalkyl, C3-C7-heterocycloalkyl, C2-C6-aminoalkyl, C2-C6-hydroxyalkyl, and acyl, optionally substituted with 1, 2, or 3 groups each independently selected from OH, halo, NH2, acyl, SO2CH3, SO3H, carboxy, carboxyl ester, carbamoyl, substituted carbamoyl, C6-aryl, heteroaryl, C1-C6-alkyl, C3-C7-cycloalkyl, C1-C6-alkyl-O—C1-C6-alkyl, C3-C7-heterocycloalkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-hydroxyalkyl, and C2-C6 alkenyloxy, wherein C3-C7-heterocycloalkyl is optionally substituted with 1, 2, or 3 groups each independently selected from C1-C6-alkyl or C1-C6-alkoxy
• R5 is selected from the group comprising C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-alkyl-O—C1-C6-alkyl, C3-C7-cycloalkyl, C1-C4-carboxyalkyl, C3-C7-heterocycloalkyl, C6-aryl, and heteroaryl optionally substituted with 1, 2, or 3 groups each independently selected from OH, halo, NH2, acyl, SO2CH3, SO3H, carboxy, carboxyl ester, carbamoyl, substituted carbamoyl, C6-aryl, heteroaryl, C1-C6-alkyl, C3-C6-cycloalkyl, C3-C7-heterocycloalkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-hydroxyalkyl, and C2-C6 alkenyloxy
• R12 and R13 are independently selected from the group comprising H, C1-C6-alkyl, C2-C6-hydroxyalkyl, C2-C6-alkyl-O—C1-C6-alkyl, C3-C7-cycloalkyl, C1-C4-carboxyalkyl, C3-C7-heterocycloalkyl, C6-aryl, heteroaryl optionally substituted with 1, 2, or 3 groups each independently selected from OH, halo, NH2, acyl, SO2CH3, SO3H, carboxy, carboxyl ester, carbamoyl, substituted carbamoyl, C6-aryl, heteroaryl, C1-C6-alkyl, C3-C6-cycloalkyl, C3-C7-heterocycloalkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-hydroxyalkyl, and C2-C6 alkenyloxy
• R12 and R13 are optionally connected to form a C3-C7 cycloalkyl ring, or a C4-C7-heterocycloalkyl ring containing 1 or 2 nitrogen, sulfur or oxygen atoms
• or a pharmaceutically acceptable salt thereof or a solvate or a hydrate of a compound of Formula I or the pharmaceutically acceptable salt thereof or a prodrug of a compound of Formula I or a pharmaceutically acceptable salt or a solvate or a hydrate thereof.