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US 2022/0009883 A1Published application
Thioamide-containing compositions and methods of use thereof
AssigneeNoria Therapeutics, Inc.
InventorStephen DIMAGNO
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Abstract
Provided herein are compositions and methods for preparing albumin-targeting moieties that feature a thioamide linkage. Methods to use the albumin targeting molecules to generate drugs with improved in vivo pharmacodynamics and biodistribution are described. Therapeutic compounds incorporating these thioamide linked albumin-targeting moieties are disclosed.
Claims22
1) A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is H, C1-C6 alkyl, or a protecting group;
- R2 is H, C1-C6 alkyl, or a protecting group;
- R3 is H, C1-C6 alkyl, or a protecting group;
- X is a therapeutic drug;
- and
- n is 0, 1, 2, 3, 4, or 5.
5 more elements
12) The compound of claim 12, wherein L2 is
21) A compound of Formula (IV):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is H, C1-C6 alkyl, or a protecting group;
- R2 is H, C1-C6 alkyl, or a protecting group;
- and
- n is 0, 1, 2, 3, 4, or 5.
3 more elements
Dependencies are inferred from the claim text.