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US 2022/0008569 A1Published application
Pet tracer for imaging of neuroendocrine tumors
AssigneeSomscan Aps
InventorsAndreas KJAER, Ulrich KNIGGE, Liselotte HØJGAARD, Palle RASMUSSEN
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Abstract
There is provided a radiolabelled peptide-based compound for diagnostic imaging using positron emission tomography (PET). The compound may thus be used for diagnosis of malignant diseases. The compound is particularly useful for imaging of somatostatin overexpression in tumors, wherein the compound is capable of being imaged by PET when administered with a target dose in the range of 150-350 MBq, such as 150-250 MBq, preferable in the range of 191-210 MBq.
Claims14
Compound of Formula I
- or a pharmaceutically acceptable salt thereof,
- for diagnostic use, wherein the compound is to be administered with a target dose in the range of 150-250 MBq.
Method for manufacturing a compound of Formula I
- said method comprising the steps:
- Mixing DOTA-TATE under presence of a scavenger, such as gentisic acid. with a water soluble 64Cu-salt in an acidic aqueous solution;
- Leaving the solution for at least 2 min;
- Passing the solution through a sterile filter;
- and
- Recovering the filtered material.
3 more elements
Dependencies are inferred from the claim text.