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US 2022/0008550 A1Published application
Compositions and methods of treating muscle atrophy and myotonic dystrophy
AssigneeAvidity Biosciences, Inc.
InventorsAndrew John GEALL, Venkata Ramana DOPPALAPUDI, David Sai-Ho CHU, Michael Caramian COCHRAN, Michael HOOD, Beatrice Diana DARIMONT, Rob BURKE, Yunyu SHI, Gulin Erdogan MARELIUS, Barbora MALECOVA
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Abstract
Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
Claims18
An polynucleotide conjugate comprising an anti-transferrin receptor antibody or antigen-binding fragment thereof conjugated to a polynucleotide that mediates RNA interference against Murf1 mRNA preferentially in a muscle cell.
Dependencies are inferred from the claim text.