Immunosuppressive antigen-specific chimeric antigen receptor treg cells for prevention and/or treatment of autoimmune and alloimmune disorders

An immunoresponses cell comprising:

• a chimeric antigen receptor (CAR) that binds to glutamic acid decarboxylase 65 kDA (GAD65) in the cell;
• the CAR comprising:
• a) an intracellular signaling domain of a CD3ξ polypeptide and an intracellular signaling domain of CD28 hinge-transmembrane-intracellular region, and
• b) an extracellular polypeptide recognizing:
• at least a part of an amino acid sequence selected from the amino acids having SEQ ID Nos:
• 1-6;
• or, at least one complete amino acid sequence selected from the amino acids having SEQ ID Nos:
• 1-6.