Therapeutic approaches for tissue reconstruction and wound healing treatment
AssigneeThe Schepens Eye Research Institute, Inc.
InventorsYang Liu, Di Chen, David A. Sullivan
Life of this patent
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Abstract
Disclosed are compositions containing a therapeutically effective amount of free recombinant or synthetic lubricin, a lubricin-supplemented preserved AM, or a lubricin-supplemented non-AM substrate for promoting tissue reconstruction and wound healing in a subject and the methods of using thereof. Lubricin-supplemented preserved amniotic membranes and lubricin-supplemented non-AM substrates, and methods of preparing thereof are also described.
Claims31
A pharmaceutical composition for treating tissue reconstruction and wound healing in a subject, comprising a therapeutically effective amount of a lubricin-supplemented preserved amniotic membrane (AM) or a lubricin-supplemented non-AM substrate.
A method of treating tissue reconstruction or wound healing in a subject, comprising contacting a wound or surgical site with a composition comprising a therapeutically effective amount of a lubricin-supplemented preserved AM or a lubricin-supplemented non-AM substrate.
-32. (canceled)
A method of preparing a lubricin-supplemented preserved amniotic membrane (AM) or a lubricin-supplemented non-AM substrate, comprising soaking, rehydrating or incubating a preserved AM or a non-AM substrate with lubricin.
-37. (canceled)
Dependencies are inferred from the claim text.