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US 2022/0008516 A1Published application
PTH Prodrugs
AssigneeAscendis Pharma Bone Diseases A/S
InventorsKennett Sprogøe, Felix Cleemann, Guillaume Maitro, Mathias Krusch, Thomas Wegge, Joachim Zettler
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Abstract
The present invention relates to PTH prodrugs, pharmaceutical compositions comprising such PTH prodrugs and their uses.
Claims8
1-18. (canceled)
A parathyroid hormone (PTH) conjugate of formula (IIf-i) or a pharmaceutically acceptable salt thereof:
- wherein
- the unmarked dashed line indicates the attachment to the N-terminal nitrogen of a PTH moiety having the sequence of SEQ ID NO:51;
- and
- the dashed line marked with the asterisk indicates attachment to a moiety
- wherein
- m and p are independently an integer ranging from and including 400 to 500.
3 more elements
A method of treating a patient having hypoparathyroidism comprising administering an effective amount of the PTH conjugate or pharmaceutically acceptable salt thereof of claim 1 or a pharmaceutical composition comprising such PTH conjugate or pharmaceutically acceptable salt thereof to the patient.
Dependencies are inferred from the claim text.