Cancer combination therapy using quinoline carboxamide derivative

An antitumor agent comprising a quinoline carboxamide derivative of formula (I) below or a pharmacologically acceptable salt thereof as an active ingredient, the antitumor agent being suitable for administration in combination with one or more cancer molecular target drugs selected from the group consisting of an ALK inhibitor, an EGFR inhibitor, a multi kinase inhibitor, a HER2/EGFR inhibitor, an mTOR inhibitor, a BRAF inhibitor, a MEK inhibitor and a BCR-ABL inhibitor:

• wherein R1, R2, R3, R4, R5 and R6 each independently represent a hydrogen atom, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, COOR7 (wherein R7 represents a substituted or unsubstituted alkyl group), or OR8 (wherein R8 represents a substituted or unsubstituted alkyl group).

(canceled)

A pharmaceutical composition comprising:

• a quinoline carboxamide derivative of formula (I) below or a pharmacologically acceptable salt thereof;
• and one or more cancer molecular target drugs selected from the group consisting of an ALK inhibitor, an EGFR inhibitor, a multi kinase inhibitor, a HER2/EGFR inhibitor, an mTOR inhibitor, a BRAF inhibitor, a MEK inhibitor and a BCR-ABL inhibitor:
• wherein R1, R2, R3, R4, R5 and R6 each independently represent a hydrogen atom, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, COOR7 (wherein R7 represents a substituted or unsubstituted alkyl group), or OR9 (wherein R8 represents a substituted or unsubstituted alkyl group).

17-18. (canceled)

A method for treating a tumor, comprising administering to a patient a therapeutically effective amount of a quinoline carboxamide derivative of formula (I) below or a pharmacologically acceptable salt thereof and one or more cancer molecular target drugs selected from the group consisting of an ALK inhibitor, an EGFR inhibitor, a multi kinase inhibitor, a HER2/EGFR inhibitor, an mTOR inhibitor, a BRAF inhibitor, a MEK inhibitor and a BCR-ABL inhibitor:

• wherein R1, R2, R3, R4, R5 and R6 each independently represent a hydrogen atom, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, COOR7 (wherein R7 represents a substituted or unsubstituted alkyl group), or OR8 (wherein R8 represents a substituted or unsubstituted alkyl group).

20-22. (canceled)

A method for enhancing an antitumor effect of one or more cancer molecular target drugs selected from the group consisting of an ALK inhibitor, an EGFR inhibitor, a multi kinase inhibitor, a HER2/EGFR inhibitor, an mTOR inhibitor, a BRAF inhibitor, a MEK inhibitor and a BCR-ABL inhibitor, the method comprising administering a therapeutically effective amount of a quinoline carboxamide derivative of formula (I) below or a pharmacologically acceptable salt thereof to a patient:

• wherein R1, R2, R3, R4, R5 and R6 each independently represent a hydrogen atom, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, COOR7 (wherein R7 represents a substituted or unsubstituted alkyl group), or OR8 (wherein R8 represents a substituted or unsubstituted alkyl group).

(canceled)