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US 2022/0008346 A1Published application
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
AssigneeVanderbilt University
InventorsJohn T. Wilson, Daniel Shae, Dinh Chuong Nguyen
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Abstract
A graft copolymer and a method of delivering an active agent to a subject are provided. The graft copolymer includes a polymer backbone, a hydrophilic segment grafted to the polymer backbone, a pH-responsive segment grafted to the polymer backbone, and an endosomal disruption segment grafted to the polymer backbone. The method of delivering an active agent to a subject includes encapsulating the active agent with the graft copolymer and administering the encapsulated active agent to the subject.
Claims20
A graft copolymer, comprising:
- a polymer backbone;
- a hydrophilic segment grafted to the polymer backbone;
- a pH-responsive segment grafted to the polymer backbone;
- and
- an endosomal disruption segment grafted to the polymer backbone.
2 more elements
Dependencies are inferred from the claim text.