Methods to control the rate of release of therapeutic agents from implantable devices
AssigneeNano Precision Medical, Inc.
InventorsRYAN OLF, Lyle Gordon, Wouter Roorda
Life of this patent
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Abstract
The present disclosure provides compositions of a therapeutic agent and a release rate controlling agent for controlling the rate of release of the therapeutic agent from a reservoir of an implantable drug delivery system. The present disclosure also includes an implantable drug delivery systems incorporating the compositions of the present disclosure as well as methods of treating diabetes using the compositions and implantable drug delivery systems.
Claims21
A method for controlling a rate of release of a therapeutic agent from an implantable device, the method comprising
- providing the device, the device comprising:
- a capsule configured for implantation and having a reservoir;
- a fluid formulation of the therapeutic agent contained within the reservoir and having a pH;
- a nanoporous membrane with a plurality of pores attached to the capsule and providing a diffusion path for release of the therapeutic agent out of the reservoir;
- wherein the rate of release of the therapeutic agent through the nanoporous membrane is dependent on the pH of the formulation;
- and
- selecting a pH of the formulation at a level suitable to achieve a desired rate of release of the therapeutic agent.
A method for controlling a rate of release of a therapeutic agent having an iso-electric point from an implantable device, the method comprising
- providing the device, the device comprising:
- a capsule configured for implantation and having a reservoir;
- a fluid formulation of the therapeutic agent contained within the reservoir and having a pH;
- a nanoporous membrane with a plurality of pores attached to the capsule and providing a diffusion path for release of the therapeutic agent out of the reservoir, the nanoporous membrane having nanopores with an interior surface, the interior surface having an iso-electric point;
- wherein the rate of release is determined by the degree of charge similarity between the therapeutic agent and the interior surface of the nanopores;
- and
- selecting a pH of the formulation to achieve the desired degree of charge similarity.
An implantable device for release of a therapeutic agent at a controlled rate, comprising
- a capsule configured for implantation and having a reservoir;
- a fluid formulation of the therapeutic agent contained within the reservoir and having a pH;
- a nanoporous membrane with a plurality of pores attached to the capsule and providing a diffusion path for release of the therapeutic agent out of the reservoir;
- wherein the rate of release of the therapeutic agent through the nanoporous membrane is dependent on the pH of the formulation;
- and
- wherein the pH of the formulation is suitable to achieve a desired rate of release of the therapeutic agent.
21-36. (canceled)
Dependencies are inferred from the claim text.