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US 2021/0403535 A1Published application
Novel polypeptides and medical uses thereof
AssigneeColzyx AB
InventorsMatthias MÖRGELIN, Suado ABDILLAHI
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AssigneeColzyx AB
InventorsMatthias MÖRGELIN, Suado ABDILLAHI
Estimating the term…
The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.
A polypeptide consisting of an amino acid sequence derived from the α3 chain of collagen type VI, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof,
A polypeptide according to any one of the preceding claims wherein the polypeptide is capable of binding to the membrane of the microorganism.
A polypeptide according to any one of the preceding claims wherein the polypeptide is capable of causing membrane disruption of the microorganisms.
A polypeptide according to any one of the preceding claims which is capable of promoting wound closure.
A polypeptide according to any one of the preceding claims, wherein the polypeptide is capable of exhibiting an antimicrobial effect greater than or equal to that of LL-37.
A polypeptide according to any one of the preceding claims wherein the microorganisms are Gram-positive or Gram-negative bacteria.
A polypeptide according to any one of the preceding claims wherein the microorganisms are bacteria which are resistant to one or more conventional antibiotic agents.
A polypeptide according to any one of the preceding claims wherein the polypeptide is substantially non-toxic to mammalian cells.
A polypeptide according to any one of the preceding claims wherein the polypeptide is capable of exerting an anti-endotoxic effect.
A polypeptide according to any one of the preceding claims wherein the polypeptide is derived from a von Willebrand Factor type A domain.
A polypeptide according to any of the preceding claims wherein the polypeptide is a fragment of the α3 chain of collagen type VI.
A polypeptide according to any one of the preceding claims wherein the polypeptide is derived from the N2, N3 or C1 domain of the α3 chain of collagen type VI.
A polypeptide according to any one of the preceding claims wherein the polypeptide has a net positive charge.
A polypeptide according to any one of the preceding claims wherein the polypeptide has at least 30% hydrophobic residues.
A polypeptide according to any one of the preceding claims comprising or consisting of the amino acid sequence selected from the group consisting of SEQ ID NOs:
A polypeptide according to any one of the preceding claims wherein the polypeptide comprises or consists of a variant of the amino acid sequence selected from the group consisting of SEQ ID NOs:
A polypeptide according to any one of the preceding claims wherein the polypeptide is between 10 and 200 amino acids in length, for example between 10 and 150, 15 and 100, 15 and 50, 20 and 40 or 25 and 35 amino acids in length.
A polypeptide according to any one of the preceding claims wherein the polypeptide, or fragment, variant, fusion or derivative thereof, comprises one or more amino acids that are modified or derivatised.
A polypeptide according to any one of the preceding claims wherein the polypeptide is a recombinant polypeptide.
A nucleic acid molecule which encodes a polypeptide according to any one of the preceding claims.
Dependencies are inferred from the claim text.