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US 2021/0401965 A1Published application
A novel dna vaccine against crimean-congo hemorrhagic fever virus (cchfv)
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsKar Muthumani, David Weiner
Life of this patent
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Abstract
Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Crimean-Congo hemorrhagic fever virus (CCHFV) antigens. Immunomodulatory methods and methods of inducing an immune response against CCHFV are disclosed. Method of preventing infection by CCHFV and methods of treating individuals infected with CCHFV are disclosed. CCHFV glycoprotein immunogens are disclosed.
Claims14
A composition comprising:
- a nucleic acid molecule comprising a nucleotide sequence that encodes a consensus Crimean-Congo hemorrhagic fever virus (CCHFV) antigen wherein the antigen comprises the amino acid sequence selected from the group consisting of:
- a) SEQ ID NO:2, a fragment of SEQ ID NO:2 that comprises 600 or more amino acids, an amino acid sequence that is at least 95% homologous to SEQ ID NO:2, a fragment of an amino acid sequence that is at least 95% homologous to SEQ ID NO:2 that comprises 600 or more amino acids;
- SEQ ID NO:2 linked to an IgE signal peptide, a fragment of SEQ ID NO:2 that comprises 600 or more amino acids linked to an IgE signal peptide, an amino acid sequence that is at least 95% homologous to SEQ ID NO:2 linked to an IgE signal peptide, and a fragment of an amino acid sequence that is at least 95% homologous to SEQ ID NO:2 that comprises 600 or more amino acids linked to an IgE signal peptide;
- b) SEQ ID NO:4, a fragment of SEQ ID NO:4 that comprises 600 or more amino acids, an amino acid sequence that is at least 95% homologous to SEQ ID NO:4, a fragment of an amino acid sequence that is at least 95% homologous to SEQ ID NO:4 that comprises 600 or more amino acids, a fragment of SEQ ID NO:4 that comprises 600 or more amino acids linked to an IgE signal peptide, an amino acid sequence that is at least 95% homologous to SEQ ID NO:4 linked to an IgE signal peptide, and a fragment of an amino acid sequence that is at least 95% homologous to SEQ ID NO:4 that comprises 600 or more amino acids linked to an IgE signal peptide.
1 more element
Dependencies are inferred from the claim text.