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US 2021/0401953 A1Published application
Asparaginase therapeutic methods
AssigneesThe Broad Institute, Inc., President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
InventorsWilliam Sellers, Haoxin Li
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Abstract
Provided herein, in some embodiments, are methods for detecting a level of asparaginase (ASNS) in a sample obtained from a subject having or at risk for stomach cancer or liver cancer, and methods of treating the subject.
Claims18
A method for treating liver cancer or stomach cancer in a subject, the method comprising:
- (a) detecting a level of asparaginase (ASNS) in a biological sample from a subject, and
- (b) administering an effective amount of a pharmaceutical composition comprising ASNS to the subject if the biological sample from the subject exhibits a decreased level of ASNS compared to the level of ASNS in a control sample or compared to a predetermined reference level of ASNS.
A method for treating liver cancer or stomach cancer in a subject, the method comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising asparaginase (ASNS).
Dependencies are inferred from the claim text.