Compositions for treating pathological calcification conditions, and methods using same
OwnerDemetrios BRADDOCK, Ronald ALBRIGHTinventors
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Abstract
The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of ENPP4.
Claims21
1-25. (canceled)
A method of treating or ameliorating thrombosis in a mammalian subject in need thereof, the method comprising administering to the mammalian subject a therapeutically effective amount of an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 4 (ENPP4), wherein the inhibitor binds to ENPP4 and inhibits ENPP4's activity.
A method of treating or ameliorating thrombosis in a mammalian subject in need thereof, the method comprising administering to the mammalian subject a therapeutically effective amount of an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 4 (ENPP4) expression.
A method of treating or ameliorating coagulopathy in a mammalian subject in need thereof, the method comprising administering to the mammalian subject a therapeutically effective amount of an isolated soluble ectonucleotide pyrophosphatase/phosphodiesterase 4 (ENPP4) polypeptide comprising amino acid residues 1-407 of SEQ ID NO:1.
Dependencies are inferred from the claim text.