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US 2021/0395309 A1Published application
Peptide-drug conjugates
AssigneeHong Kong Baptist University
InventorsZhaoxiang BIAN, Tao HUANG, Xuanming GUO, Chengyuan LIN
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Abstract
Provided herein are Bradykinin-potentiating peptide chemotherapeutic drug conjugates useful as cancer therapeutics, pharmaceutical compositions comprising the same, and methods of preparation and use thereof.
Claims20
A peptide-drug conjugate (PDC) of Formula I:
- R1—X—R2 I
- or a pharmaceutically acceptable salt or zwitterion thereof, wherein
- X is a linker;
- R1 is a chemotherapeutic agent;
- R2 is a Bradykinin-potentiating polypeptide, wherein the linker is covalently bonded to the N-terminal nitrogen of the Bradykinin-potentiating polypeptide.
2 more elements
Dependencies are inferred from the claim text.