Non-hydrogen-bonding universal reader for dna sequencing
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsPeiming Zhang, Sovan Biswas, Suman Sen, Stuart Lindsay
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Abstract
The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.
Claims20
A compound of formula (I):
- wherein R1 is (C1-C6) alkyl or (C1-C6) alkoxy;
- R2 is selected from the group consisting of thiol, disulfide, and amine;
- and
- R3 is H, an electron withdrawing group or an electron donating group;
- ring A or ring B is substituted with R1-R2;
- and
- ring C or ring D is substituted with R3;
- provided that (i) when ring A is substituted with R1-R2, ring C is substituted with R3;
- and (ii) when ring B is substituted with R1-R2, ring D is substituted with R3.
A compound of formula (I):
- wherein R1 is (C1-C3) alkyl;
- R2 is thiol;
- and
- R3 is H;
- ring A or ring B is substituted with R1-R2;
- and
- ring C or ring D is substituted with R3;
- provided that (i) when ring A is substituted with R1-R2, ring C is substituted with R3;
- and (ii) when ring B is substituted with R1-R2, ring D is substituted with R3.
Dependencies are inferred from the claim text.