Purity detection of separated sample portion as basis for a positive or negative decision concerning further separation

A sample separation apparatus for separating a fluidic sample, the sample separation apparatus comprising:

• an initial dimension sample separation device configured for separating the fluidic sample in accordance with a first separation criterion;
• a subsequent dimension sample separation device configured for further separating separated fluidic sample received from the initial dimension sample separation device in accordance with a second separation criterion;
• a purity detector configured for detecting information indicative of a purity of a portion of the fluidic sample which has been separated by the initial dimension sample separation device, wherein the purity is indicative whether the portion of fluidic sample has substantially only a single component or is composed of multiple different components which can be further separated;
• and
• a control unit configured for controlling, depending on the detected information, whether or not further separation of the portion of the fluidic sample which has been separated by the initial dimension sample separation device is carried out by the subsequent dimension sample separation device.