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US 2021/0381013 A1Published application
Enzymatic cyclization of homofarnesylic acid
AssigneeBASF SE
InventorsMichael BREUER, Wolfgang SIEGEL, Stefan RÜDENAUER, Ralf PELZER
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Abstract
The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.
Claims16
-15. (canceled)
A process for the biocatalytic preparation of a compound of the general formula II,
- wherein R1, R2, R3 and R4 independently of one another represent H or C1-C4-alkyl,
- in stereoisomerically pure form or as a mixture of stereoisomers,
- wherein the compound is brought into contact with a protein, which protein is capable of cyclizing a polyunsaturated carboxylic acid, in particular homofarnesylic acid.
Dependencies are inferred from the claim text.