Inhibitors of the wnt/beta-catenin pathway

A compound of Formula I, Formula II, Formula III:

• or a pharmaceutically acceptable salt thereof, wherein,
• X is C═O, NR3, C═NR3, S, S═O, S(═O)2, or C═S;
• Y is heteroaryl, aryl, or C(O)N(R7)(R4);
• R1 and R2 are independently selected from aryl, heteroaryl, and heterocyclyl;
• R4 is hydrogen, alkyl, alkenyl, acyl, aryl, heteroaryl, C(O)aryl, C(O)alkyl, C(O)Oalkyl, C(O)Oaryl, C(O)Oheteroaryl, C(O)N(R5aR5b), aralkyl, alkylsulfonyl, or
• R5a and R5b are independently selected from H, alkyl, aralkyl, and aryl;
• R6 is H, alkyl, or aryl;
• and
• R3 and R7 are each independently H or alkyl.