Method and device of treating chronic kidney disease-associated pruritus
AssigneeAvior, Inc.
InventorNiraj Vasisht
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Abstract
The presently disclosed subject matter is directed to an effective method of treating chronic kidney disease-associated pruritus. Particularly, the method comprises the transmucosal administering of nalmefene to treat chronic kidney disease-associated pruritus, as well as cholestatic pruritus and/or prurigo nodularis. The nalmefene can be configured in a single layer film comprising at least two distinct domains. The film can include a first discrete domain comprising about 50-100 weight percent polymer matrix and the second discrete domain can comprise the nalmefene or pharmaceutically acceptable nalmefene salt.
Claims32
A method of treating pruritus in a subject, the method comprising transmucosally administering to a subject in need of such treatment a therapeutically effective amount of nalmefene or a pharmaceutically acceptable salt thereof.
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A single layer, self-supporting, mucoadhesive film device comprising:
- a first discrete domain comprising about 50 to about 100 weight percent polymer matrix and about 0 to about 50 weight percent of one or more of a permeation enhancer, pH adjusting buffer, taste masking agent, and flavoring agent, based on the total weight of the first discrete domain;
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- a second discrete domain comprising the nalmefene or pharmaceutically acceptable nalmefene salt;
- wherein the second discrete domain is non-self-supporting.
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Dependencies are inferred from the claim text.