Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions
AssigneeEmpirico Inc.
InventorsShannon BRUSE, Brian CAJES, Omri GOTTESMAN, David ROZEMA, David LEWIS
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Abstract
Molecules for inhibiting arachidonate 15-lipoxygenase (ALOX-15) gene products including dsRNA (dsRNA) agents such as small interfering RNAs (siRNAs), antisense oligonucleotides, and small molecule inhibitors for therapeutic use. Additionally provided are methods to inhibit the expression of a target gene by administering these agents for the treatment of diseases involving ALOX-15 gene products.
Claims51
A method of treating one or more disorders of the upper and lower airway in a subject in need thereof comprising administering to the subject an inhibitor of arachidonate 15-lipoxygenase (ALOX15) wherein the one or more disorders of the upper and lower airway comprises nasal polyposis, chronic sinusitis, allergic rhinitis, asthma, or NSAID-exacerbated respiratory disease.
A composition comprising an inhibitor of ALOX15 that is efficacious in treating nasal polyposis, chronic sinusitis, allergic rhinitis, asthma, or NSAID-exacerbated respiratory disease.
A method of treating one or more disorders of the upper and lower airway in a subject in need thereof comprising editing an ALOX15 gene in the subject wherein the one or more disorders of the upper and lower airway comprises nasal polyposis, chronic sinusitis, allergic rhinitis, asthma, or NSAID-exacerbated respiratory disease.
A composition comprising CRISPR/cas9 that targets ALOX15 that is efficacious in treating nasal polyposis, chronic sinusitis, allergic rhinitis, asthma, or NSAID-exacerbated respiratory disease.
Dependencies are inferred from the claim text.