Method And System For Analyzing A Sample Desorbed At Different Temperatures Using Cavity Ring-Down Spectroscopy, And A Method For Generating A Predictive Model

A system for analyzing a sample using cavity ring-down spectroscopy, comprising:

• a ring-down cavity;
• at least one laser operable to generate a laser beam at each of a set of wavelengths, the laser beam being directed into the ring-down cavity;
• a sample-loading system for loading at least part of a sample into the ring-down cavity for analysis, and for unloading the at least part of the sample from the ring-down cavity;
• a light intensity sensor system positioned to register light intensity decay data for light exiting the ring-down cavity;
• at least one processor operably coupled to the sample-loading system, the at least one laser, and the light intensity sensor system;
• a storage storing computer-readable instructions that, when executed by the at least one processor, cause the at least one processor to:
• control the sample-loading system to load the at least part of the sample into the ring-down cavity;
• for each of the set of wavelengths:
• operate the at least one laser to generate the laser beam directed into the ring-down cavity;
• extinguish the laser beam entering the ring-down cavity;
• and
• register light intensity decay data for light exiting the ring-down cavity via the light intensity sensor system;
• and
• determine a probability from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of a physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or absence of the physiological condition or the degree of the physiological condition has been identified.

A method for analyzing a sample using cavity ring-down spectroscopy, comprising:

• heating a thermal desorption tube to a first desorption temperature to desorb a first part of a sample contained therein;
• loading the first part of the sample into a ring-down cavity;
• for each of a first set of wavelengths:
• generating, via at least one laser, a laser beam at the wavelength that is directed into the ring-down cavity;
• extinguishing the laser beam entering the cavity;
• and
• registering light intensity decay data for light exiting the ring-down cavity via a light intensity sensor system;
• unloading the first part of the sample from the ring-down cavity;
• heating the thermal desorption tube to a second desorption temperature to desorb a second part of the sample contained therein;
• loading the second part of the sample into the ring-down cavity;
• for each of a second set of wavelengths:
• generating, via the at least one laser, a laser beam at the wavelength that is directed into the ring-down cavity;
• extinguishing the laser beam entering the cavity;
• and
• registering light intensity decay data for light exiting the ring-down cavity via the light intensity sensor system;
• and
• analyzing the light intensity decay data desorbed at the first desorption temperature and the light intensity decay data desorbed at the second desorption temperature.