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US 2021/0355520 A1Published application
Method for the production of amino sugar containing products
AssigneeUniversiteit Gent
InventorsJo Maertens, David Bauwens, Wouter Van Bellegem, Pieter Coussement, Dries Duchi, Marjan De Mey
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Abstract
A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.
Claims17
1-16. (canceled)
A method of producing at least one specialty product selected from the group consisting of:
- UDP-N-acetylglucosamine (UDP-GlcNAc),
- a UDP-GlcNAc-derived saccharide,
- a UDP-GlcNAc-derived nucleoside,
- a UDP-GlcNAc-derived glycolipid,
- a UDP-GlcNAc-derived glycoside,
- a UDP-GlcNAc-derived glycoprotein,
- a UDP-GlcNAc-derived glycosylphosphate,
- a UDP-GlcNAc-derived glycosylsulphate,
- a saccharide derived from a UDP-GlcNAc-derived nucleoside,
- a nucleoside or glycolipid derived from a UDP-GlcNAc-derived nucleoside,
- a glycoside derived from a UDP-GlcNAc-derived nucleoside,
- a glycoprotein derived from a UDP-GlcNAc-derived nucleoside,
- a glycosylphosphate derived from a UDP-GlcNAc-derived nucleoside, and
- a glycosylsulphate derived from a UDP-GlcNAc-derived nucleoside, wherein the method comprises:
- a) decreasing synthesis or activity of at least one essential enzyme involved in peptidoglycan biosynthesis, pseudopeptidoglycan biosynthesis, UDP-N-acetylmuramoyl-pentapeptide biosynthesis, lipid IVA biosynthesis, or chitin biosynthesis in a suitable microorganism without reducing the microorganism's cell growth,
- b) cultivating the microorganism wherein endogenous UDP-GlcNAc is the building block of both production of specialty carbohydrates and biomass formation, and
- c) extracting and purifying the selected specialty product(s).
14 more elements
Dependencies are inferred from the claim text.