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US 2021/0348124 A1Published application
Sebaceous gland organoids and use thereof
AssigneeTechnion Research & Development Foundation Limited
InventorsYaron FUCHS, Alona FELDMAN
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Abstract
Sebaceous gland-like organoids comprising a Blimp1 positive cell are provided. Methods of producing the organoids and using the organoids to test a skin drug are also provided; as are methods of treating acne.
Claims30
A sebaceous gland (SG)-like organoid, comprising:
- a. an outer layer of cells, wherein said outer layer comprises a proliferating cell, a stem cell and a B-lymphocyte-induced nuclear maturation protein 1 (Blimp1) expressing cell;
- and
- b. an inner core of non-proliferating cells wherein said inner core comprise a Blimp1 expressing cell.
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A method of treating acne in a subject in need thereof, the method comprising decreasing c-Myc expression, function or both in a sebaceous gland of said subject, thereby treating acne in a subject.
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Dependencies are inferred from the claim text.