# US 2021/0340693 A1 · Fiber and method for preparing the same and artificial ligament/tendon

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- Number: US 2021/0340693 A1
- Document ID: US20210340693A1
- Status: Published application
- Kind: A1
- Application number: 17/244,742
- Filed: 2021-04-29
- Published: 2021-11-04
- Earliest claimed: 2020-04-29
- Assignees: Industrial Technology Research Institute
- Applicants: Industrial Technology Research Institute
- Inventors: Shinn-Jen CHANG; Wesley Jen-Yang CHANG; Hsin-Hsin SHEN; Pei-Yi TSAI
- Web page: https://patentgrep.com/patent/US20210340693A1

## CPC

- D01F 8/14: with at least one polyester as constituent
- D02G 3/448: {Yarns or threads for use in medical applications (D02G3/449 takes precedence; surgical suture materials A61L17/00)}
- A61F 2/08: Muscles; Tendons; Ligaments
- A61L 27/46: with phosphorus-containing inorganic fillers
- B29C 48/05: Filamentary, e.g. strands
- C08J 3/226: {using a polymer as a carrier}
- D01D 5/00: Formation of filaments, threads, or the like
- D01F 1/10: Other agents for modifying properties
- D01F 6/62: from polyesters
- D01F 8/18: from other substances
- D02G 3/04: Blended or other yarns or threads containing components made from different materials
- A61F 2210/00: Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F 2230/0069: cylindrical
- A61F 2240/001: Designing or manufacturing processes
- A61L 2430/10: for reconstruction of tendons or ligaments
- B29C 48/505: Screws
- B29L 2031/7532: {Artificial members, protheses}
- C08J 2367/02: Polyesters derived from dicarboxylic acids and dihydroxy compounds; (C08J2367/06 takes precedence)
- C08J 2467/02: Polyesters derived from dicarboxylic acids and dihydroxy compounds (C08J2467/06 takes precedence)
- D10B 2101/08: Ceramic
- D10B 2331/04: polyesters, e.g. polyethylene terephthalate [PET]
- D10B 2401/061: elastic
- D10B 2509/00: Medical; Hygiene
- D01F: CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D02G: CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)
- D01D: MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES

## Abstract

A method of preparing fiber includes blending bio-compatible ceramic powder and first polyester to form a ceramic powder composition, wherein the bio-compatible ceramic powder and the first polyester have a weight ratio of 10:90 to 60:40. The method further includes blending the ceramic powder composition and second polyester to form a composite material, wherein the ceramic powder composition and the second polyester have a weight ratio of 0.4:99.6 to 40:60. The method also spins the composite material to form a fiber. The first polyester has an intrinsic viscosity (IV) of 0.35 dL/g to 0.55 dL/g, and the second polyester has an intrinsic viscosity (IV) of 0.6 dL/g to 0.8 g/dL. The fiber can be woven to form an artificial ligament/tendon.

## Claims

### Claim 1

A fiber, comprising:
0.5 to 4 parts by weight of a bio-compatible ceramic powder region; and
96 to 99.5 parts by weight of a polyester region,
wherein the bio-compatible ceramic powder region is distributed in the polyester region, at least 90% of the bio-compatible ceramic powder region has a diameter of less than or equal to 300 nm and greater than 10 nm, and the cell viability of bio-toxicity test of the fiber is higher than 70%.

### Claim 2 (depends on 1)

The fiber as claimed in claim 1, having a diameter of 2 micrometers to 150 micrometers.

### Claim 3 (depends on 1)

The fiber as claimed in claim 1, wherein the polyester region comprises polyethylene terephthalate, polybutylene terephthalate, or a combination thereof, and the bio-compatible ceramic powder region comprises hydroxyapatite, tricalcium phosphate, calcium sulfate, or a combination thereof.

### Claim 4 (depends on 1)

The fiber as claimed in claim 1, being free of dispersant.

### Claim 5 (depends on 1)

The fiber as claimed in claim 1, having a cell viability of bio-toxicity test higher than 100%.

### Claim 6 (depends on 1)

An artificial ligament/tendon, being woven from the fiber as claimed in claim 1.

### Claim 7

A method of preparing a fiber, comprising:
blending bio-compatible ceramic powder and first polyester to form a ceramic powder composition, wherein the bio-compatible ceramic powder and the first polyester have a weight ratio of 10:90 to 60:40;
blending the ceramic powder composition and second polyester to form a composite material, wherein the ceramic powder composition and the second polyester have a weight ratio of 0.4:99.6 to 40:60; and
spinning the composite material to form a fiber,
wherein the first polyester has an intrinsic viscosity (IV) of 0.35 dL/g to 0.55 dL/g, and the second polyester has an intrinsic viscosity (IV) of 0.6 dL/g to 0.8 g/dL.

### Claim 8 (depends on 7)

The method as claimed in claim 7, wherein the fiber comprises:
0.5 to 4 parts by weight of a bio-compatible ceramic powder region; and
96 to 99.5 parts by weight of a polyester region,
wherein the bio-compatible ceramic powder region is distributed in the polyester region, at least 90% of the bio-compatible ceramic powder region has a diameter of less than or equal to 300 nm and greater than 10 nm, and the cell viability of bio-toxicity test of the fiber is higher than 70%.

### Claim 9 (depends on 7)

The method as claimed in claim 7, wherein the fiber has a diameter of 2 micrometers to 150 micrometers.

### Claim 10 (depends on 1)

The method as claimed in claim 1, wherein the first polyester and the second polyester comprise polyethylene terephthalate, polybutylene terephthalate, or a combination thereof, and the bio-compatible ceramic powder comprises hydroxyapatite, tricalcium phosphate, calcium sulfate, or a combination thereof.

### Claim 11 (depends on 7)

The method as claimed in claim 7, wherein the fiber is free of dispersant.

### Claim 12 (depends on 7)

The method as claimed in claim 7, wherein the intrinsic viscosity difference (ΔIV) between the first polyester and the second polyester is greater than or equal to 0.1 dL/g and less than or equal to 0.45 dL/g.