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US 2021/0340569 A1Published application
Novel aav8 mutant capsids and compositions containing same
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M. Wilson, Qiang Wang
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Abstract
Provided herein are AAV8 mutant capsids and rAAV comprising the same. In one embodiment, vectors employing the AAV8 mutant capsid show increased transduction in a selected tissue as compared to AAV8.
Claims5
An adeno-associated virus comprising a capsid having the sequence of SEQ ID NO:
- 18 (AAV3G1), SEQ ID NO:
- 20 (AAV8.T20);
- or SEQ ID NO:
- 22 (AAV8.TR1).
1 more element
A recombinant adeno-associated virus (AAV) comprising an AAV capsid having an amino acid sequence selected from:
- SEQ ID NO:
- 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32 and 34, further comprising a non-AAV nucleic acid sequence.
A nucleic acid molecule comprising a nucleic acid sequence encoding an AAV capsid protein, wherein said nucleic acid sequence is selected from SEQ ID NO:
- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31 and 33.
Dependencies are inferred from the claim text.