Nucleic acid molecules inserted expression regulation sequences, expression vector comprising nucleic acid moleclues and pharmaceutical use thereof
AssigneeThe Catholic University of Korea Industry-Academic Cooperation Foundation
InventorsJae Hwan NAM, Hyo Jung PARK, Hae Li KO, Hun KIM, Hae Won KWAK
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Abstract
A nucleic acid molecule including at least one expression control sequence having an Internal Ribosomal Entry Site (IRES) sequence, at least one coding region, and optionally multiple adenosines or thymidines upstream of the at least one expression control sequence is disclosed as an expression system. Besides, a recombinant expression vector including the nucleic acid molecule and pharmaceutical or medicinal use of the nucleic acid molecule are disclosed.
Claims21
A nucleic acid molecule comprising:
- at least one expression control sequence comprising a viral Internal Ribosomal Entry Site (IRES) element having a viral 5′ untranslated region (5′ UTR);
- at least one coding region linked operatively to the at least one expression control sequence and encoding a peptide or a protein;
- and
- at least one of multiple adenosines and multiple thymidines located upstream of the at least one expression control sequence.
A method of stimulating an immune response in a subject, the method comprising administering a pharmaceutically effective amount of a nucleic acid molecule, wherein the nucleic acid molecule comprising:
- at least one expression control sequence comprising a viral Internal Ribosomal Entry Site (IRES) element having a viral 5′ untranslated region (5′ UTR).
Dependencies are inferred from the claim text.