Dysregulation of covid-19 receptor associated with ibd
AssigneeCedars-Sinai Medical Center
InventorsDermot MCGOVERN, Alka POTDAR, Shishir DUBE
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Abstract
Provided herein are methods, systems and kits for use in identifying a subject with an increased risk of developing severe forms of inflammatory bowel disease (IBD), based at least in part, on an expression of one or more biomarkers detected in a biological sample obtained from the subject. Also provided are methods, systems and kits for treating, or optimizing the treatment for, the IBD based, at least in part, on the expression the one or more biomarkers. In some embodiments, the one or more biomarkers is angiotensin-converting enzyme 2 (ACE2), the host receptor for severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2).
Claims20
A method of treating an inflammatory, fibrostenotic, or fibrotic disease or condition in a subject, the method comprising:
- administering a therapeutic agent to the subject based, at least in part, on an expression level of a biomarker comprising angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), transmembrane serine protease 4 (TMPRSS4), solute carrier family 6 member 19 (SLC6A19), Sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1), or Janus kinase 1 (JAK1), or a combination thereof, as compared to an expression level of the biomarker in a control sample obtained from a subject that does not have the inflammatory, fibrostenotic, or fibrotic disease or condition.
Dependencies are inferred from the claim text.