# US 2021/0332004 A1 · Polyfunctional cannabinoids

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2021/0332004 A1
- Document ID: US20210332004A1
- Status: Published application
- Kind: A1
- Application number: 17/229,041
- Filed: 2021-04-13
- Published: 2021-10-28
- Earliest claimed: 2020-04-23
- Assignees: Axim Biotechnologies, Inc.
- Applicants: Axim Biotechnologies, Inc.
- Inventors: Sergei Svarovsky; John W. Huemoeller, II
- Web page: https://patentgrep.com/patent/US20210332004A1

## CPC

- C07C 235/48: having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- C07C 235/60: having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07D 311/80: Dibenzopyrans; Hydrogenated dibenzopyrans
- C07C 2601/16: the ring being unsaturated
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

This invention discloses cannabinoids linked with polyethylene glycol chains. The cannabinoid-polyethylene glycol chain molecules have one, two, or more cannabinoids linked with one, two, or more polyethylene glycol chains. Each cannabinoid-polyethylene glycol chain molecule may have one kind of cannabinoid or multiple kinds of cannabinoid. Methods to make these cannabinoid-polyethylene glycol linked chains are disclosed.

## Claims

### Claim 1

A compound having the formula:
X—[CO—HN—(O—CH2—CH2)n]—CH3
wherein X is a cannabinoid having a phenolic group, and
wherein X is linked to —[CO—HN—(O—CH2—CH2)n]—CH3 at the carbon at the 2′ position on the phenolic ring.

### Claim 2 (depends on 1)

The compound of claim 1, wherein n is 7 to give the formula:

### Claim 3 (depends on 1)

The compound of claim 1, wherein X is:

### Claim 4

A compound having the formula:
where in X is a cannabinoid having a phenolic group,
wherein Y is a cannabinoid having a phenolic group and Y is different from X,
wherein X is linked to —[CO—HN—(O—CH2—CH2)n] at the carbon at the 2′ position on the phenolic ring, and
wherein Y is linked to —[CO—HN—(O—CH2—CH2)n] at the carbon at the 2′ position on the phenolic ring.

### Claim 5 (depends on 4)

The compound of claim 4, wherein X and Y are the same.

### Claim 6 (depends on 4)

The compound of claim 4, wherein X is:
and
Y is different from X and is one of:

### Claim 7 (depends on 4)

The compound of claim 4, wherein X and Y are the same and are:

### Claim 8

A compound having the formula:
where in X is a cannabinoid having a phenolic group,
wherein Y is a cannabinoid having a phenolic group and Y is different from X,
wherein Z is a cannabinoid having a phenolic group and Z is different from X and Y
wherein X is linked to —[CO—HN—(O—CH2—CH2)n] at the carbon at the 2′ position on the phenolic ring,
wherein Y is linked to —[CO—HN—(O—CH2—CH2)n] at the carbon at the 2′ position on the phenolic ring, and
wherein Z is linked to —[CO—HN—(O—CH2—CH2)n] at the carbon at the 2′ position on the phenolic ring.

### Claim 9 (depends on 8)

The compound of claim 8, wherein X, Y, and Z are:

### Claim 10 (depends on 8)

The compound of claim 8, wherein X, Y, and Z are the same cannabinoid.

### Claim 11 (depends on 11)

The compound of claim 11, wherein X, Y, and Z are:

### Claim 12 (depends on 8)

The compound of claim 8, wherein two of X, Y, and Z are the same cannabinoid and the third is a different cannabinoid.

### Claim 13 (depends on 12)

The compound of claim 12, wherein X, Y, and Z are:

### Claim 14

A compound having the formula:
wherein X is a cannabinoid having a phenolic group, and
wherein X is linked to —[COO—(O—CH2—CH2)n] at the carbon at the 2′ position on the phenolic ring.

### Claim 15 (depends on 14)

The compound of claim 14, wherein X is:

### Claim 16

A compound having the formula:
wherein X is a cannabinoid having a phenolic group,
wherein Y is an amine, hydroxy, or sulfhydryl group, and
wherein X is linked to —[Y—(O—CH2—CH2)n] at the carbon at the 2′ position on the phenolic ring.

### Claim 17 (depends on 16)

The compound of claim 16, wherein X is: