# US 2021/0330959 A1 · Device and a method for providing resuscitation or suspended state in cardiac arrest

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- Number: US 2021/0330959 A1
- Document ID: US20210330959A1
- Status: Published application
- Kind: A1
- Application number: 17/369,437
- Filed: 2021-07-07
- Published: 2021-10-28
- Earliest claimed: 2014-05-26
- Assignees: Neurescue ApS
- Applicants: Neurescue ApS
- Inventors: Habib Frost
- Web page: https://patentgrep.com/patent/US20210330959A1

## CPC

- A61H 31/007: {Manual driven}
- A61F 7/12: Devices for heating or cooling internal body cavities
- A61M 5/1723: {using feedback of body parameters, e.g. blood sugar or pressure}
- A61M 60/113: in other functional devices, e.g. dialysers or heart-lung machines
- A61M 60/139: inside the aorta, e.g. intra-aortic balloon pumps
- A61M 60/148: in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
- A61M 60/295: Balloon pumps for circulatory assistance
- A61M 60/31: for enhancement of in vivo organ perfusion, e.g. retroperfusion
- A61M 60/497: for balloon pumps for circulatory assistance
- A61M 60/508: Electronic control means, e.g. for feedback regulation
- A61F 2007/126: {for invasive application, e.g. for introducing into blood vessels}
- A61M 60/274: the inlet and outlet being the same, e.g. para-aortic counter-pulsation blood pumps
- A61M 60/414: transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
- A61M 2205/054: with electrotherapy
- A61M 2205/071: hand operated
- A61M 2205/3334: Measuring or controlling the flow rate
- A61M 2205/3375: Acoustical, e.g. ultrasonic, measuring means
- A61M 2205/3379: Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M 2205/3507: with implanted devices, e.g. external control
- A61M 2205/50: with microprocessors or computers
- A61M 2205/502: User interfaces, e.g. screens or keyboards
- A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient
- A61M 2205/581: by audible feedback
- A61M 2205/587: Lighting arrangements
- A61M 2205/702: automatically during use
- A61M 2205/8206: battery-operated
- A61M 2230/005: Parameter used as control input for the apparatus
- A61M 2230/04: Heartbeat characteristics, e.g. ECG, blood pressure modulation
- A61M 2230/30: Blood pressure (A61M2230/04 takes precedence)
- A61M 2230/43: Composition of exhalation
- A61M 2230/50: Temperature
- A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient. The device includes an electrically controllable redistribution component attachable to the patient to provide redistribution of the cardiac output to increase supply to the brain and heart. The redistribution component, following a predefined reaction pattern based on an electrical signal, and computer means configured to: receive a patient data which identifies physiological and/or anatomical characteristics of the patent; and provide the electrical signal for the redistribution component based on the patient data or a standard response. The device may provide mechanisms to protect the aorta and the remaining anatomy of the patient from inadvertent damage caused by the disclosed device in any usage scenario of either correct intended usage or unintended usage. Also disclosed is a method for providing resuscitation or suspended state.

## Claims

### Claim 1

A device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient, the device comprising
an electrically or manually controllable redistribution component attachable to the patient and being configured to interact with the patient to provide redistribution of the cardiac output to increase supply to the brain and heart, the redistribution component following a predefined reaction pattern based on an electrical signal, and
computer means configured to:
receive a patient data which identifies physiological and/or anatomical characteristics of the patient; and
provide the electrical signal for controlling the redistribution component and/or for presenting the physiological and/or anatomical characteristics for a user based on the patient data or a standard response.

### Claim 2 (depends on 1)

The device according to claim 1, where the computer means comprises memory means having stored therein a predefined definition of the electrical signal as a response to the patient data.

### Claim 3 (depends on 1, 2)

The device according to claim 1 or 2, comprising patient data generation means configured to generate patient data during external cardiac compression carried out on the patient, the patient data generation means configured to generate the patient data by sensing biosignals from the patient.

### Claim 4 (depends on 3)

The device according to claim 3, where the patient data generation means is configured to sense biosignals from a blood vessel or a tissue compartment.

### Claim 5

The device according to any one of the preceding claims, wherein the redistribution component comprises or consists of an aortic retrograde perfusion pump.

### Claim 6 (depends on 1, 2, 3, 4)

The device according to any of claims 1-4, where the redistribution component comprises an elongated body extending between a proximal end and a distal end, the distal end being insertable into the patient, where the redistribution component comprises an aortic expansion member and inflation means connected to the aortic expansion member for expanding the aortic expansion member.

### Claim 7 (depends on 6)

The device according to claim 6, wherein the inflation means is adapted to be capable of being operated manually by a user.

### Claim 8 (depends on 6, 7)

The device according to claim 6 or 7, wherein the inflation means is adapted to be capable of being operated automatically.

### Claim 9 (depends on 6, 7, 8)

The device according to any one of claims 6-8, further comprising an adaptable tissue protection mechanism configured to:
determine a blood pressure or blood flow present in a blood vessel of the patient during cardiac compression;
determine an aortic expansion member characteristics defining a degree of expansion of the aortic expansion member based on the determined blood pressure or blood flow; and
to provide an electrical signal for controlling the inflation means in accordance with the determined aortic expansion member characteristics.

### Claim 10 (depends on 9)

The device according to claim 9, where the adaptable tissue protection mechanism is configured to determine the aortic expansion member characteristics based on the determined blood pressure or blood flow multiplied by a predetermined factor.

### Claim 11 (depends on 6, 7, 8, 9, 10)

The device according to any of claims 6-10, where the electrical signal specifies a degree of expansion of the aortic expansion member, a timing of expansion of the aortic expansion member, an upper limit of expansion, a duration of expansion of the aortic expansion member, and/or a timing of contraction of the aortic expansion member.

### Claim 12 (depends on 6, 7, 8, 9, 10, 11)

The device according to any of claims 6-11, where the inflation means comprises a piston or roller pump.

### Claim 13

The device according to 6-12, further comprising a location safety mechanism comprising at least one first sensor capable of determining a biosignal which is characteristic for aorta of the patient and an electronic circuit configured to verify a position of the expansion member in aorta based on the biosignal.

### Claim 14 (depends on 13)

The device according to claim 13, where the at least one first sensor comprises a pressure sensor.

### Claim 15 (depends on 13, 14)

The device according to claim 13 or 14, where the first sensor is located on the redistribution component to determine the biosignal in a position distal to the aortic expansion member.

### Claim 16 (depends on 15)

The device according to claim 15, where the device is configured to use data from the first sensor in combination with data from sensors located at other locations.

### Claim 17 (depends on 16)

The device according to claim 16, where at least one of the other sensors is located on the redistribution component to determine the biosignal in a position proximal to the aortic expansion member.

### Claim 18 (depends on 13, 14, 15, 16, 17)

The device according to any of claims 13-17, where the location safety mechanism is configured to determine whether the aortic expansion member is located in a position selected from a group consisting of: a pulsating vessel in accordance with being the aorta of the patient, a pulsating vessel not in accordance with being the aorta, a pulsating vessel being indeterminate as the aorta of the patient, a venous vessel, a tissue compartment not being a blood vessel and a tissue compartment indeterminate in location.

### Claim 19 (depends on 13, 14, 15, 16, 17, 18)

The device according to any of claims 13-18, further comprising a second sensor inside the aortic expansion member or proximal to the expansion member.

### Claim 20 (depends on 13, 14, 15, 16, 17, 18, 19)

The device according to any of claims 13-19, wherein the device is configured with a feedback loop receiving data from at least one of the first and second sensor, to control the filling of the aortic expansion member.

### Claim 21 (depends on 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)

The device according to any of the claims 6-20, further comprising a first failsafe mechanism, configured to determine a pressure in the aortic expansion member and to determine a volume of the aortic expansion member, to determine a ratio between the pressure and the volume, and to compare the ratio with an upper and lower threshold value, and to execute a control sequence including stopping of further inflation of the aortic expansion member or deflation of the aortic expansion member.

### Claim 22 (depends on 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)

The device according to any of claims 6-21, further comprising a user interface for use of selectable operation of the inflation means.

### Claim 23 (depends on 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)

The device according to any of claims 6-22, comprising a halt interface allowing manually selectable deflation of the aortic inflation member.

### Claim 24 (depends on 23)

The device according to claim 23, where the halt interface is configured to execute the selectable deflation over a predefined number of seconds.

### Claim 25 (depends on 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)

The device according to any of claims 6-24, comprising a patient state monitor configured to determine a biosignal representing Return of Spontaneous Circulation (ROSC), and to control deflation of the aortic expansion member based on the determined signal.

### Claim 26 (depends on 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)

The device according to any of claims 6-25, further comprising an electronic human interface with a graphical or audio user interface configured to provide instructions or information related to the location and degree of filling of the aortic expansion member in the aorta of the patient, said human interface optionally being attachable in a fixed position on a patient.

### Claim 27 (depends on 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)

The device according to any of claims 6-26, further comprising at least one sensor for determining pressure, flow, O2 saturation or concentration, and/or volume data significant for pressure, flow and/or volume of a fluid inside the aortic expansion member or inside a blood vessel or tissue of the patient.

### Claim 28 (depends on 27)

The device according to claim 27, where the computer means is configured to compare the pressure, flow and/or volume data with reference input data and based on the comparison to verify a position of the aortic expansion member in the body.

### Claim 29 (depends on 27, 28)

The device according to claim 27 or 28, where the computer means is configured to determine the size and type of blood vessel by analyzing the pressure flow and/or volume data continuously.

### Claim 30 (depends on 27, 28, 29)

The device according to any one of claims 27-29, where the computer means is configured to activate a failsafe for some verified positions in the body or limits based on sensor data analysis, thereby stopping the redistribution component interaction with the patient, the expansion of the aortic member or initiation of contraction of the aortic member.

### Claim 31 (depends on 27, 28, 29, 30)

The device according to any one of claims 27-30, wherein an interactive human user guide is configured to provide information related to a position of the aortic expansion member in the patient, the information being determined based on the pressure, flow and/or volume data.

### Claim 32

The device according to any of the preceding claims, further comprising means for ultrasound imaging data in the guidance of the user.

### Claim 33

The device according to any of the preceding claims, where the patient data includes parameters selected from the group consisting of: aortic blood pressure, aortic blood flow, duration of cardiac arrest, expiratory CO2, ECG, blood pressure, compression rate and depth, pulse, respiratory frequency, cardiac output redistribution degree, aortic O2 saturation or concentration, cerebral or peripheral saturation, temperature, fluid administered, pharmaceuticals administered, biochemical data, and ultrasound imaging.

### Claim 34 (depends on 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)

The device according to any of claims 5-30, where the aortic expansion member comprises an aortic occluding balloon.

### Claim 35 (depends on 34)

The device according to claim 34, further compromising means for filling the aortic occluding balloon with a liquid or a gas.

### Claim 36 (depends on 35)

The device according to claim 35, further comprising a handheld unit comprising the computer means and the filling means and being attachable to the aortic occluding balloon.

### Claim 37 (depends on 26, 35, 36)

The device according to claim 35, further comprising an human interface unit comprising the filling means and being attachable to the aortic occluding balloon, said human interface optionally being attachable in a fixed position on a patient and wherein said human interface is optionally integrated with the human interface defined in claim 26 and/or the handheld unit defined in claim 36.

### Claim 38 (depends on 36, 37)

The device according to claim 36 or 37, wherein the aortic occluding balloon is pre-attached to the handheld unit.

### Claim 39

The device according to any of the preceding claims, where the computer means is configured to receive input data from the redistribution component.

### Claim 40

The device according to any of the preceding claims, further comprising a component attachable to the patient and being configured to administer fluids and drugs to the patient.

### Claim 41 (depends on 40)

The device according to claim 40, further compromising the means to administer timed and controlled amount of fluids and/or drugs.

### Claim 42

The device according to any of the preceding claims, further comprising an additional component from the group consisting of: a patient monitor, a vitals signs monitor, a watch, an external chest compression device, a respirator, an ECG monitor, a defibrillator, a pacemaker, a pH measurement device, an ultrasound device, an ECMO/ECLS device, a body cooling device, an infusion pump, a capnograph, a ventricular assist device, a dialysis device, touchscreen and/or telecommunications device.

### Claim 43

The device according to any of the preceding claims, the redistribution component comprising of a component with the means for tilting the patient in a head down or head up tilt.

### Claim 44

The device according to any of the preceding claims, further comprising means for a self-test system, double circuitry, and usage event data recording.

### Claim 45

The device according to any one of the preceding claims, wherein the computer means communicates with at least one other therapeutic and/or monitoring device so as to allow coordination of the operation of said therapeutic devices and the device according to any one of the preceding claims.

### Claim 46 (depends on 45)

The device according to claim 45, wherein the at least one other therapeutic and/or monitoring device is selected from a cardiac resynchronization therapy device, a cardioverter-defibrillator, and a cardiac pacemakers.

### Claim 47

A method for providing resuscitation or suspended state in a human cardiac arrest patient, said method comprising subjecting the patient to heart massage (chest compression) while at the same time ensuring redistribution of the cardiac output to preferentially supply blood to the brain and the heart.

### Claim 48 (depends on 47)

The method according to claim 47, wherein said redistribution is accomplished by at least one of the following:
occlusion of the aorta caudal to the left subclavian artery;
head-down or head-up tilting of the patient so as to reach an angle of between 30 and 90 degrees relative to the horizontal plane;
applying an external compression force onto the abdomen and/or thigh(s) and/or arm(s) so as to reduce the perfusion distal to the external compression force;
passively raising the legs to reach an angle between 30 and 90 degrees relative to the horizontal plane.

### Claim 49 (depends on 47, 48)

The method according to claim 47 or 48, wherein said chest compression is manual or accomplished by use of a mechanical chest compression device.

### Claim 50 (depends on 47, 48, 49)

The method according to any one of claims 47-49, wherein at least one of the following treatments is/are also provided to the patient:
administration of fluids, including saline and buffers such as bicarbonate,
administration of vasopressive drugs, including vasopressin and analogues,
administration of a tissue-protecting agent, such as erythropoietin;
administration of anti-arrhythmic drug, such as amiodarone;
reduction of body temperature, such as by use of cold IV-fluid infusion, cooling catheters, transnasal evaporative cooling, extracorporeal cooling or total liquid ventilation with temperature controlled perfluorocarbons.

### Claim 51 (depends on 50)

The method according to claim 50, wherein the treatments are provided repeatedly, optionally according to a fixed sequence.

### Claim 52 (depends on 47, 48, 49, 50, 51)

The method according to any one of claims 47-51, which comprises that redistribution is accomplished by occlusion of the aorta caudal to the left subclavian artery.

### Claim 53 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 52)

The method according to claim 52, wherein occlusion is accomplished by introducing a device according to any one of claims 1-46 into the aorta, preferably via the femoral artery, and subsequently decreasing or interrupting the blood flow distal to the redistribution component by expanding the redistribution component of said device.

### Claim 54 (depends on 53)

The method according to claim 53, wherein the redistribution component is expanded in a controlled manner in response to measurement(s) that indicate the degree of occlusion and correct placement of said device in the patient's aorta.

### Claim 55 (depends on 54)

The method according to claim 54, wherein said measurement(s) is/are selected from the group consisting of:
duration of expansion redistribution component usage;
blood flow passing by the redistribution component;
blood pressure distal of the redistribution component, optionally combined with blood pressure proximal to the redistribution component;
aortic O2 saturation distal of, and preferably in close proximity to, the redistribution component, optionally combined with arterial O2 saturation proximal of the redistribution component.

### Claim 56 (depends on 9, 53, 54, 55)

The method according to any one of claims 53-55, wherein expansion of the redistribution component is controlled manually or by the computer means of said device to avoid incorrect positioning or expansion degree of said device and by activating the failsafe of claim 9 in case said device is verified to be incorrectly positioned thereby interrupting the expansion of the redistribution component to allow subsequent correct positioning.

### Claim 57 (depends on 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)

The method according to any one of claim 47-56, wherein the redistribution is temporarily interrupted at regular or irregular intervals so as to ensure sufficient perfusion of all parts of the body of the patient.

### Claim 58 (depends on 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)

The method according to any one of claims 47-57, which acts during or as a bridge to one or more of
therapeutic hypothermia; angioplasty, including PCI and angiography; dialysis; administration of drugs such as vasopressors, thrombolytic drugs such as fibrinolytics, fluids, bicarbonate, antidotes, and antiarrhythmic drugs; the use of ultrasound, X-ray, CT, or MR; intubation; mechanical ventilation; ventricular assist devices; heart transplantation, including artificial heart transplantation; surgery, including CABG surgery and valve surgery; blood transfusion; placement of external or internal pacemaker or ICD; catheter ablation; thromboendarterectomy; defibrillation; transportation; ECMO; ECLS and cardiopulmonary bypass.

### Claim 59 (depends on 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)

The method according to any one of claims 47-58, further comprising lowering the restriction on perfusion delivered to the brain and heart through the use of a vasodilator, hereunder specifically sodium nitroprusside or nitroglycerin and repeated administration of sodium nitroprusside or nitroglycerin, hereunder repetition in intervals of 2-10 minutes.

### Claim 60 (depends on 59)

The method according to claim 59, further comprising the use of an aortic expansion member to prevent the systemic vascular collapse caused by the vasodilator.

### Claim 61

The method according to any one of the preceding claims, further comprising the use of any one of the following: active compression-decompression CPR, impedance threshold device, adenosine administration, controlled pauses in the CPR (e.g. compressions for 20 seconds, then a pause in compressions for 20 seconds.)

### Claim 62

A method for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a human in cardiac arrest or imminent cardiac arrest, the method comprising subjecting the patient to external chest compression while at the same time ensuring redistribution of the cardiac output accomplished by occlusion of the aorta caudal to the left subclavian artery, and comprising lowering the restriction on perfusion delivered to the brain and heart through the use of a vasodilator, hereunder specifically sodium nitroprusside or nitroglycerin, hereunder repetition in intervals of 2-10 minutes.

### Claim 63 (depends on 62)

A method according to claim 62, further acting as a bridge to one or more of the following:
ECMO; ECLS; cardiopulmonary bypass; angioplasty, including PCI and angiography; dialysis;
therapeutic hypothermia, hereunder cold IV-fluid infusion, cooling catheters, transnasal evaporative cooling, extracorporeal cooling or total liquid ventilation; administration of drugs, hereunder vasopressors or vasodilators, hereunder sodium nitroprusside or nitroglycerin, thrombolytic drugs such as fibrinolytics, fluids, bicarbonate, antidotes, tissue-protecting agents and antiarrhythmic drugs, such as amiodarone; the use of ultrasound, X-ray, CT, or MR; intubation; mechanical ventilation; ventricular assist devices; surgery, including CABG surgery and valve surgery; blood transfusion; placement of external or internal pacemaker or ICD; catheter ablation; thromboendarterectomy; heart transplantation; defibrillation; transportation.

### Claim 64

A method for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a human in cardiac arrest or imminent cardiac arrest, the method comprising subjecting the patient to external chest compression while at the same time ensuring redistribution of the cardiac output accomplished by sustained abdominal compression or abdominal binding, and comprising lowering the restriction on perfusion delivered to the brain and heart through the use of a vasodilator, hereunder specifically sodium nitroprusside or nitroglycerin, hereunder repetition in intervals of 2-10 minutes, and comprising acting as a bridge to one or more of the following:
ECMO; ECLS; cardiopulmonary bypass; angioplasty, including PCI and angiography; dialysis; therapeutic hypothermia, hereunder cold IV-fluid infusion, cooling catheters, transnasal evaporative cooling, extracorporeal cooling or total liquid ventilation; administration of drugs, hereunder vasopressors or vasodilators, hereunder sodium nitroprusside or nitroglycerin, thrombolytic drugs such as fibrinolytics, fluids, bicarbonate, antidotes, tissue-protecting agents and antiarrhythmic drugs, such as amiodarone; the use of ultrasound, X-ray, CT, or MR; intubation; mechanical ventilation; ventricular assist devices; surgery, including CABG surgery and valve surgery; blood transfusion; placement of external or internal pacemaker or ICD; catheter ablation; thromboendarterectomy; heart transplantation; defibrillation; transportation.

### Claim 65

A method for stopping or reducing bleeding from tissue(s) or organ(s), hereunder during e.g. surgery or other situations where bleeding occur of said tissue(s) or organ(s), the method comprising inserting an occlusion device into a blood vessel, which supplies said tissue(s) or organ(s) with blood, wherein said occlusion device is reversibly expanded to occlude said blood vessel and wherein the pressure exerted by the expanded occlusion device on the wall of the blood vessel is adapted to be between 1 and 2 times the vascular pressure difference across the occlusion device.

### Claim 66 (depends on 65)

The method according to claim 65, wherein the pressure exerted by the expanded occlusion device on the wall of the blood vessel is adapted to be at most 1.9 times the vascular pressure difference across the occlusion device, such as at most 1.8, at most 1.7, at most 1.6, at most 1.5, at most 1.4, at most 1.3, at most 1.2 and at most 1.1 times.

### Claim 67 (depends on 65, 66)

The method according to claim 65 or 66, wherein the occlusion device includes or is attached to at least one vascular pressure sensor, which can determine the vascular pressure in said blood vessel.

### Claim 68 (depends on 67)

The method according to claim 67, wherein the at least one pressure sensor is positioned in said vessel between the occlusion in said vessel and said tissue(s) or organ(s) and/or is positioned in the part of said vessel which is separated from said tissue(s) or organ(s) by the occlusion.

### Claim 69 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 65, 66, 67, 68)

The method according to any one of claims 65-68, wherein the occlusion device is part of a device as claimed in any one of claims 1-46, where said occlusion device is identical to the aortic expansion member of claim 6 or may be a modified version of said aortic expansion member, which is adapted be able to fit into other blood vessels.
