# US 2021/0330875 A1 · Filter and Frame Apparatus and Method of Use > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0330875 A1 - Document ID: US20210330875A1 - Status: Published application - Kind: A1 - Application number: 17/369,905 - Filed: 2021-07-07 - Published: 2021-10-28 - Earliest claimed: 2011-12-29 - Assignees: Delcath Systems, Inc. - Applicants: Delcath Systems, Inc. - Inventors: William M. Appling; Stephen N. Engelhard; Matthew G. Barton - Web page: https://patentgrep.com/patent/US20210330875A1 ## CPC - A61M 1/3626: {Gas bubble detectors} - A61M 1/3615: {Cleaning blood contaminated by local chemotherapy of a body part temporarily isolated from the blood circuit} - A61M 1/3639: {Blood pressure control, pressure transducers specially adapted therefor} - A61M 1/3679: {by absorption (A61M1/3675 takes precedence)} - B01D 25/002: {Clamping devices (B01D25/12 and subgroups take precedence)} - B01D 29/52: in parallel connection - B01D 35/306: {Filter mounting adapter} - A61M 2202/0057: retained by adsorption - A61M 2202/0413: Blood - B01D 24/002: {with multiple filtering elements in parallel connection} - Y10T 29/49826: Assembling or joining - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) - Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ## Abstract Provided is a filter apparatus, comprising two or more filter cartridges having a first end with an inlet and screen and a second end with an outlet and screen, and walls to contain a filter media held in a housing for holding the two or more filter cartridges in about the same orientation, and an attachment clamp connected to the housing. Also provided is a housing for holding two or more filter cartridges in about the same orientation and a method of using the filter apparatus and housing. ## Claims ### Claim at position 1 1-20. (canceled) ### Claim 21 A kit for delivering a chemotherapeutic agent to a liver of a patient, comprising: an isolation-aspiration catheter, and a filter apparatus comprising two or more filter cartridges mounted in a single frame housing, wherein the housing comprises an upper plate and a lower plate for holding the two or more filter cartridges in about the same orientation, the upper plate and the lower plate comprising openings for rotatably engaging the two or more filter cartridges, and an attachment clamp. ### Claim 22 (depends on 21) A kit according to claim 21, further comprising a venous return sheath ### Claim 23 (depends on 21) A kit according to claim 21, further comprising a venous return catheter. ### Claim 24 (depends on 21) A kit according to claim 21, further comprising a hepatic arterial infusion catheter. ### Claim 25 (depends on 21) A kit according to claim 21, further comprising melphalan hydrochloride. ### Claim 26 (depends on 21) A kit according to claim 21, further comprising an extracorporeal circuit. ### Claim 27 (depends on 21) A kit according to claim 21, wherein the two or more filter cartridges extend through the openings of the upper plate, the lower plate, or the upper and lower plates. ### Claim 28 (depends on 21) A kit according to claim 21, wherein the filter apparatus is a dual cartridge. ### Claim 29 (depends on 21) A kit according to claim 21, wherein the isolation-aspiration catheter is a double balloon catheter. ### Claim 30 (depends on 21) A kit according to claim 21, wherein the attachment clamp is a pole clamp. ### Claim 31 A kit for delivering a chemotherapeutic agent to a liver of a patient, comprising: an isolation-aspiration catheter, and a filter apparatus, comprising two or more filter cartridges having a first end with an inlet and screen and a second end with an outlet and screen, and walls to contain a filter media; a housing comprising an upper plate and a lower plate for holding the two or more filter cartridges in about the same orientation, the upper plate and the lower plate comprising openings for rotatably engaging the two or more filter cartridges, and one or more support elements connecting the upper plate and the lower plate. ### Claim 32 (depends on 31) A kit according to claim 31, further comprising a venous return sheath. ### Claim 33 (depends on 31) A kit according to claim 31, further comprising a venous return catheter. ### Claim 34 (depends on 31) A kit according to claim 31, further comprising a hepatic arterial infusion catheter. ### Claim 35 (depends on 31) A kit according to claim 31, further comprising melphalan hydrochloride. ### Claim 36 (depends on 31) A kit according to claim 31, further comprising an extracorporeal circuit. ### Claim 37 (depends on 31) A kit according to claim 31 further comprising a pole clamp connected to the housing. ### Claim 38 (depends on 31) A kit according to claim 31, wherein the two or more filter cartridges extend through the openings, the upper plate (1) and the lower plate (1). ### Claim 39 (depends on 31) A kit according to claim 31, wherein the walls to contain the filter media comprise a cartridge ### Claim 40 (depends on 31) A kit according to claim 31, wherein the filter media comprises activate carbon. ### Claim 41 (depends on 31) A kit according to claim 31, wherein the filter media is hydrogel coated activated carbon. ### Claim 42 (depends on 31) A kit of parts according to claim 31, wherein the isolation-aspiration catheter is a double balloon catheter. ### Claim 43 A kit for delivering a chemotherapeutic agent to a liver of a patient, comprising: an isolation aspiration catheter; a filter apparatus comprising two or more filter cartridges each filter cartridge comprising a first end with an inlet, and a first screen, a second end with an outlet and a second screen, and walls configured to contain a filter media and comprising a cartridge tube, wherein the outlet of each filter cartridge is connected to an outlet connector by an outlet flange; a housing comprising an upper plate and a lower plate oriented substantially parallel to each other and configured to hold the two or more filter cartridges in about the same orientation, the upper plate and the lower plate each defining two or more openings to which the two or more filter cartridges are rotatably coupled and wherein the outlet flange connected to each outlet connector extends through the two or more openings of the upper plate, and an attachment clamp connected to the housing. ### Claim 44 (depends on 43) A kit for delivering a chemotherapeutic agent to a liver of a patient according to claim 43, wherein the housing further comprises one or more support elements connecting the upper plate and the lower plate. ### Claim 45 (depends on 43) The filter apparatus of claim 43, wherein the cartridge tube is comprised of a transparent material selected from the group consisting of a polysulfone, a polycarbonate, a polypropylene and an acrylic. ### Claim 46 (depends on 43) The filter apparatus of claim 43, wherein the filter media is hydrogel coated activated carbon. ### Claim 47 (depends on 43) A kit according to claim 43, further comprising a venous return sheath. ### Claim 48 (depends on 43) A kit according to claim 43, further comprising a venous return catheter. ### Claim 49 (depends on 43) A kit according to claim 43, further comprising a hepatic arterial infusion catheter. ### Claim 50 (depends on 43) A kit according to claim 43, further comprising melphalan hydrochloride. ### Claim 51 (depends on 43) A kit according to claim 43, further comprising an extracorporeal circuit. ### Claim 52 (depends on 43) A kit according to claim 43, wherein the filter apparatus is a dual cartridge. ### Claim 53 (depends on 43) A kit according to claim 43, wherein the isolation-aspiration catheter is a double balloon catheter. ### Claim 54 A percutaneous hepatic perfusion (PHP) system for delivering high-dose chemotherapy to the liver, comprising: an isolation-aspiration catheter; and a filter apparatus comprising two or more filter cartridges mounted in a single frame housing, wherein the housing comprises an upper plate and a lower plate for holding the two or more filter cartridges in about the same orientation, the upper plate and the lower plate comprising openings for rotatably engaging the two or more filter cartridges, and an attachment clamp. ### Claim 55 (depends on 54) A percutaneous hepatic perfusion (PHP) system for delivering high-dose chemotherapy to the liver according to claim 54, further comprising a venous return sheath ### Claim 56 (depends on 54) A percutaneous hepatic perfusion (PHP) system for delivering high-dose chemotherapy to the liver according to claim 54, further comprising a venous return catheter ### Claim 57 (depends on 54) A percutaneous hepatic perfusion (PHP) system for delivering high-dose chemotherapy to the liver according to claim 54, further comprising a hepatic arterial infusion catheter. ### Claim 58 (depends on 54) A percutaneous hepatic perfusion (PHP) system for delivering high-dose chemotherapy to the liver according to claim 54, further comprising an extracorporeal circuit.