# US 2021/0330752 A1 · Feed supplements

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- Number: US 2021/0330752 A1
- Document ID: US20210330752A1
- Status: Published application
- Kind: A1
- Application number: 17/357,668
- Filed: 2021-06-24
- Published: 2021-10-28
- Earliest claimed: 2018-12-31
- Assignees: OmniGen Research, LLC
- Applicants: OmniGen Research, LLC
- Inventors: A. Bruce Johnson
- Web page: https://patentgrep.com/patent/US20210330752A1

## CPC

- A23K 20/147: Polymeric derivatives, e.g. peptides or proteins
- A61K 38/30: Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 {(insulin-like growth factor binding protein A61K38/1754)}
- A23K 10/18: of live microorganisms
- A23K 10/30: from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms (obtained by microbiological or biochemical processes, e.g. using yeasts or enzymes, A23K10/10)
- A23K 20/10: Organic substances
- A23K 20/105: Aliphatic or alicyclic compounds
- A23K 20/111: Aromatic compounds
- A23K 20/121: containing oxygen or sulfur as hetero atom
- A23K 20/137: containing two hetero atoms, of which at least one is nitrogen
- A23K 20/142: Amino acids; Derivatives thereof
- A23K 20/163: Sugars; Polysaccharides
- A23K 20/168: Steroids
- A23K 20/174: Vitamins
- A23K 20/184: Hormones
- A23K 20/189: Enzymes
- A23K 20/195: Antibiotics
- A23K 20/28: Silicates, e.g. perlites, zeolites or bentonites
- A23K 20/30: {Oligoelements}
- A23K 50/10: for ruminants
- A23K 50/20: for horses
- A23K 50/30: for swines
- A23K 50/70: for birds
- A23K 50/75: for poultry
- A23K 50/80: for aquatic animals, e.g. fish, crustaceans or molluscs
- A61K 31/105: Persulfides (thiuram disulfides A61K31/145; thiosulfonic acids A61K31/185)
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/26: Iron; Compounds thereof
- A61K 33/34: Copper; Compounds thereof
- A61K 35/742: Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
- A61K 36/06: Fungi, e.g. yeasts
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/896: Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K 38/1841: {Transforming growth factor [TGF]}
- A61K 38/47: acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A61K 38/51: Lyases (4)
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/02: Inorganic compounds
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23K: FODDER
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Disclosed herein are embodiments of a combination and/or composition comprising a growth factor and one or more of silica, mineral clay, glucan, mannans, endoglucanohydrolase, yucca, quillaja, metal chelate, chromium compound, probiotic, polyphenol, direct fed microbial, copper species, vitamin, allicin, alliin, alliinase, yeast, growth promotant, preservative, antimicrobial, or vaccine. The growth factor may be an active growth factor such as an active insulin-like growth factor. Also disclosed are methods of administering the combination and/or composition to an animal. The combination and/or composition may provide a beneficial effect to the animal upon administration, such as, but not limited to, improved immune function, metabolism, milk production, growth, feed conversion, fertilization, reproduction, oocyte quality in a ruminant undergoing superovulation, embryo viability, muscle growth, muscle percentage, heart muscle development, egg product and/or quality, sperm production and/or quality, meat quality, or a combination thereof.

## Claims

### Claim 1

A combination and/or composition comprising a growth factor and one or more of quillaja, yucca, probiotic, chromium compound, silica, mineral clay, glucan, mannans, endoglucanohydrolase, metal chelate, polyphenol, plant extract, copper species, vitamin, allicin, alliin, alliinase, yeast, growth promotant, preservative, antimicrobial, or vaccine.

### Claim 2 (depends on 1)

The combination and/or composition of claim 1, wherein the growth factor comprises an active insulin-like growth factor (IGF), an active transforming growth factor, or a combination thereof.

### Claim 3 (depends on 1)

The combination and/or composition of claim 1, wherein the growth factor is an active insulin-like growth factor (IGF).

### Claim 4 (depends on 1)

The combination and/or composition of claim 1, comprising Yucca schidigera or an extract thereof, and Quillaja saponaria or an extract thereof.

### Claim 5 (depends on 4)

The combination and/or composition of claim 4, wherein an amount of quillaja is from 70% to less than 100% of an amount of yucca and quillaja in the combination and/or composition.

### Claim 6 (depends on 1)

The combination and/or composition of claim 1, wherein the probiotic is a direct fed microbial.

### Claim 7 (depends on 6)

The combination and/or composition of claim 6, wherein the direct fed microbial comprises Bacillus coagulans, Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens, or any combination thereof.

### Claim 8 (depends on 1)

The combination and/or composition of claim 1, wherein:
the chromium compound is chromium picolinate, chromium tripicolinate, chromium nicotinate, chromium polynicotinate, chromium acetate, chromium propionate, chromium histidinate, chromium nicotinate-glycinate, chromium glycinate, chromium aspartate, chromium methionine, chromium trimethionine, chromium phenylalanine, chromium chloride, chromium bromide, chromium iodine, chromium fluoride, chromium yeast, chromium carbonate, chromium nitrate, chromium sulfate, chromium phosphate, chromium nitrite, or a combination thereof; and
the metal chelate is ferric tyrosine, ferric citrate, ferric lactate, ferric proteinate, ferric lysine, or a combination thereof.

### Claim 9 (depends on 1)

The combination and/or composition of claim 1, wherein the combination and/or composition comprises 1-40 wt % silica, 0.5-25 wt % glucan and mannans, 40-92 wt % mineral clay, and 0.05-3% endoglucanohydrolase in amounts relative to each other.

### Claim 10 (depends on 1)

The combination and/or composition of claim 1, further comprising a feed.

### Claim 11 (depends on 10)

The combination and/or composition of claim 10, wherein the combination and/or composition comprises from greater than zero to 500 grams of the growth factor per ton (2000 pounds) of the feed.

### Claim 12 (depends on 10)

The combination and/or composition of claim 10, wherein the combination and/or composition comprises from 50 to 300 grams of the growth factor and from 250 to 500 grams of yucca and quillaj a, or extracts thereof, per ton of feed.

### Claim 13 (depends on 10)

The combination and/or composition of claim 10, wherein the feed comprises an increased nutrient density compared to a comparable standard feed.

### Claim 14 (depends on 13)

The combination and/or composition of claim 13, wherein the increased nutrient density comprises an increased amount of energy, protein, amino acid, mineral, vitamin, or a combination thereof, compared to an amount of energy, protein, amino acid, mineral, vitamin, or a combination thereof, provided by the standard feed.

### Claim 15 (depends on 1)

The combination and/or composition of claim 1, comprising a first composition comprising active IGF and a second composition comprising one or more of yucca or an extract thereof, quillaja or an extract thereof, a direct fed microbial, chromium compound, silica, mineral clay, glucan, mannans, or endoglucanohydrolase.

### Claim 16 (depends on 15)

The combination and/or composition of claim 15, wherein the second composition comprises:
yucca and quillaj a, or extracts thereof;
Bacillus coagulans, Bacillus subtilis, Bacillus licheniformis, and Bacillus amyloliquefaciens;
a chromium compound selected from chromium picolinate, chromium nicotinate, chromium propionate, chromium tripicolinate, chromium methionine, or a combination thereof;
silica, mineral clay, glucan, mannans and endoglucanohydrolase; or
a combination thereof.

### Claim 17 (depends on 1)

A method, comprising administering to an animal a combination and/or composition according to claim 1.

### Claim 18 (depends on 17)

The method of claim 17, wherein the animal is:
a bovine, pig, sheep, goat, horse, donkey, deer, elk, alpaca, camel or llama;
an avian selected from a chicken, turkey, goose, duck, Cornish game hen, quail, partridge, pheasant, guinea-fowl, ostrich, emu, swan, or pigeon; or
an aquatic species.

### Claim 19 (depends on 18)

The method of claim 18, wherein the avian is a chicken or turkey.

### Claim 20 (depends on 17)

The method of claim 17, wherein the growth factor comprises an active IGF.

### Claim 21 (depends on 17)

The method of claim 17, wherein the combination and/or composition comprises:
Yucca schidigera or an extract thereof, and Quillaja saponaria or an extract thereof;
silica, mineral clay, glucan, mannans and endoglucanohydrolase;
a probiotic comprising Bacillus coagulans, Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens or a combination thereof;
a metal chelate selected from ferric tyrosine, ferric citrate, ferric lactate, ferric proteinate, ferric lysine or a combination thereof;
a chromium compound selected from chromium picolinate, chromium nicotinate, chromium propionate, chromium tripicolinate, chromium methionine, or a combination thereof; or
a combination thereof.

### Claim 22 (depends on 17)

The method of claim 17, wherein administering the combination and/or composition to the animal comprises administering an amount of the combination and/or composition sufficient to provide a beneficial result to the animal.

### Claim 23 (depends on 22)

The method of claim 22, wherein the beneficial result is improving immune function, metabolism, milk production, growth, feed conversion, fertilization, reproduction, oocyte quality in a ruminant undergoing superovulation, embryo viability, muscle growth, muscle percentage, heart muscle development, egg product and/or quality, sperm production and/or quality, meat quality, or a combination thereof

### Claim 24 (depends on 17)

The method of claim 17, further comprising administering to the animal a feed comprising an increased nutrient density compared to a standard feed for the animal, wherein the increased nutrient density comprises an increased amount of energy, protein, amino acid, mineral, vitamin, or a combination thereof, compared to an amount of energy, protein, amino acid, mineral, vitamin, or a combination thereof, provided by a standard feed.

### Claim 25 (depends on 17)

The method of claim 17, wherein administering the combination and/or composition comprises administering sequentially in any order within an effective time period, a first composition comprising the growth factor, and a second composition comprising one or more of:
Yucca schidigera or an extract thereof, and Quillaja saponaria or an extract thereof silica, mineral clay, glucan, mannans and endoglucanohydrolase;
a probiotic comprising Bacillus coagulans, Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens or a combination thereof;
a metal chelate selected from ferric tyrosine, ferric citrate, ferric lactate, ferric proteinate, ferric lysine or a combination thereof or
a chromium compound selected from chromium picolinate, chromium nicotinate, chromium propionate, chromium tripicolinate, chromium methionine, or a combination thereof.