# US 2021/0330702 A1 · Tetrathionate for Cyanide and Methylmercaptan Poisoning

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- Number: US 2021/0330702 A1
- Document ID: US20210330702A1
- Status: Published application
- Kind: A1
- Application number: 17/271,284
- Filed: 2019-08-20
- Published: 2021-10-28
- Earliest claimed: 2018-08-28
- Assignees: The Regents of the University of California; The Regents of the University of Colorado
- Applicants: The Regents of the University of California; The Regents of the University of Colorado
- Inventors: Gerry R. Boss; Adriano Chan; Matthew Brenner; Sari Brenner Mahon; Vikhyat Bebarta
- Web page: https://patentgrep.com/patent/US20210330702A1

## CPC

- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61P 39/02: Antidotes
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/0043: {Nose}
- G01N 33/52: Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper {and including single- and multilayer analytical elements (immunological elements G01N33/54386; involving labelled immunochemicals G01N33/58; for haemoglobin or occult blood G01N33/72)}
- G01N 2800/709: Toxin induced
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Provided is a method, and pharmaceutical composition, to treat or prevent cyanide poisoning and/or methylmercaptan poisoning comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection or by intranasal administration. Also provided is a method for detecting the presence of tetrathionate in a sample by reacting it with cyanide and measuring the resulting thiocyanate with ferric nitrate.

## Claims

### Claim 1

A method of treating or preventing cyanide poisoning or methylmercaptan poisoning in a subject comprising administering to a subject in need an effective amount of tetrathionate by intranasal instillation.

### Claim 2 (depends on 1)

The method of claim 1, wherein the subject has cyanide poisoning.

### Claim 3 (depends on 1)

The method of claim 1, wherein the subject has methylmercaptan poisoning.

### Claim 4 (depends on 1)

The method of claim 1, wherein the subject is a human.

### Claim 5 (depends on 1)

The method of claim 1, wherein the effective amount is 0.5 to 50 mg/kg.

### Claim 6 (depends on 1)

The method of claim 1, wherein the effective amount is 1 to 25 mg/kg.

### Claim 7 (depends on 1)

The method of claim 1, wherein the effective amount is 2.5 to 10 mg/kg.

### Claim 8 (depends on 1)

The method of claim 1, wherein the effective amount is about 5.2 mg/kg.

### Claim 9

A method of treating or preventing cyanide poisoning or methylmercaptan poisoning in a subject comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection.

### Claim 10 (depends on 9)

The method of claim 9, wherein the subject has cyanide poisoning.

### Claim 11 (depends on 9)

The method of claim 9, wherein the subject has methylmercaptan poisoning.

### Claim 12 (depends on 9)

The method of claim 9, wherein the subject is a human.

### Claim 13 (depends on 9)

The method of claim 9, wherein the effective amount is 0.5 to 50 mg/kg.

### Claim 14 (depends on 9)

The method of claim 9, wherein the effective amount is 1 to 25 mg/kg.

### Claim 15 (depends on 9)

The method of claim 9, wherein the effective amount is 2.5 to 10 mg/kg.

### Claim 16 (depends on 9)

The method of claim 9, wherein the effective amount is about 5.2 mg/kg.

### Claim 17

A method of measuring tetrathionate in a biological sample comprising:
reacting the biological sample with cyanide to produce thiocyanate;
reacting the thiocyanate with ferric nitrate; and
detecting a colorimetric change indicating the presence of tetrathionate in the sample.

### Claim 18 (depends on 17)

The method of claim 17, wherein the biological sample is human blood or plasma.