# US 2021/0330700 A1 · Methods and compositions for inhibiting influenza viruses using low molecular weight hydrophobically modified polymers and polyalkylene glycols > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0330700 A1 - Document ID: US20210330700A1 - Status: Published application - Kind: A1 - Application number: 16/856,801 - Filed: 2020-04-23 - Published: 2021-10-28 - Earliest claimed: 2020-04-23 - Assignees: Johnson & Johnson Consumer Inc. - Applicants: Johnson & Johnson Consumer Inc. - Inventors: Elizabeth Bruning; Kimberly Capone; Lisa Renee Gandolfi; Anthony Robert Geonnotti, III; Euen Thomas Ekman-Gunn; Diana Roshek Johnson; Frank J. Kirchner; Selina Moses; Delores Santora; Russel Walters; Frank C. Sun - Web page: https://patentgrep.com/patent/US20210330700A1 ## CPC - A61K 31/78: of acrylic acid or derivatives thereof - A61P 31/12: Antivirals - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 31/77: of oxiranes - A61P 31/16: for influenza or rhinoviruses - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract This invention relates to methods and compositions for inhibiting the transmission of influenza viruses, which entails applying a composition containing a polyalkylene glycol compound to an infectable or ingestible surface that may contain viruses. It further relates to methods and compositions for inhibiting the transmission of influenza and other enveloped viruses, which entails applying a composition containing a polyalkylene glycol compound and a low molecular weight hydrophobically-modified polymer to an infectable or ingestible surface that may contain viruses. ## Claims ### Claim 1 A method of inhibiting entry of influenza viruses into cells comprising contacting said viruses with an anti-viral composition comprising at least one polyalkylene glycol compound having a molecular weight in an amount effective to inhibit entry of viruses into cells. ### Claim 2 A method of inhibiting entry of influenza and other enveloped viruses into cells comprising contacting said viruses with an anti-viral composition comprising at least one polyalkylene glycol compound having a molecular weight from in an amount effective to inhibit entry of viruses into cells and at least one low molecular weight hydrophobically-modified polymer. ### Claim 3 (depends on 1) A method according to claim 1 further comprising applying said anti-viral composition to infectable surfaces of a subject. ### Claim 4 (depends on 1) A method according to claim 1 wherein said infectable surfaces comprise one or more of the group consisting of skin and mucosal tissue of a subject. ### Claim 5 (depends on 3) A method according to claim 3 wherein said mucosal tissue comprises tissue selected from the group consisting of oral tissue, ocular tissue, nasal tissue, vaginal tissue, or rectal tissue and a combination thereof. ### Claim 6 (depends on 1) A method according to claim 1 wherein said low molecular weight hydrophobically modified polymer is selected from the group consisting of low-molecular weight acrylic, polysaccharide, cellulose, starch polymers, other ethylenically-unsaturated polymers, polyesters, polycarbonates, polyanhydrides, polyamides, polyurethanes, polyureas, polyimides, polysulfones, polysulfides, combinations of two or more thereof, and the like. ### Claim 7 (depends on 6) A method according to claim 6 wherein said low molecular weight hydrophobically modified polymer comprises a polymer derived from at least one first monomeric component selected from the group consisting of (meth)acrylic acid and at least one second monomeric component selected from the group consisting of one or more C1 to C9 alkyl (meth)acrylates, wherein the low molecular weight copolymer has a number average molecular weight of about 100,000 or less. ### Claim 8 (depends on 1) A method according to claim 1 wherein said low molecular weight hydrophobically modified polymer is present in said composition in an amount of from about 0.00005% to about 3% percent by weight of the composition. ### Claim 9 (depends on 1) A method according to claim 1 wherein said composition further comprises at least 55% of water. ### Claim 10 (depends on 9) A method according to claim 9 wherein said composition comprises at least 97% of water. ### Claim 11 (depends on 2) A method according to claim 2 wherein said viruses are selected from the group consisting of influenza, poxviridae, herpesviridae, retroviridae Lentivirus and a combination thereof. ### Claim 12 (depends on 1) A method according to claim 1 wherein said polyalkylene glycol is selected from the group consisting of polyethylene glycol and polypropylene glycol and a mixture thereof. ### Claim 13 (depends on 12) A method according to claim 12 wherein said polyalkylene glycol is polyethylene glycol having a molecular weight from about 200 to about 2,000,000. ### Claim 14 (depends on 13) A method according to claim 13 wherein said polyalkylene glycol is polyethylene glycol having a molecular weight from about 6,000 to about 200,000. ### Claim 15 (depends on 1) A method according to claim 1 wherein said inhibition of influenza virus entry into said cells results in the reduction of potential for viral infection. ### Claim 16 (depends on 1) A method according to claim 1 wherein the anti-viral composition does not substantially disrupt biological surfaces. ### Claim 17 A method of inactivating enveloped viruses comprising contacting infectable surfaces with an anti-viral composition comprising at least one low molecular weight hydrophobically modified polymers in an amount effective to inhibit entry of viruses into cells, wherein said composition is substantially free of surfactant. ### Claim 18 (depends on 18) A method of inhibiting entry of influenza viruses according to claim 18 further comprising contacting said viruses with said anti-viral composition. ### Claim 19 An anti-viral composition comprising at least one low molecular weight hydrophobically modified polymers and at least one polyalkylene glycol in an amount effective to inhibit entry of viruses into cells and at least 55% water, wherein said composition is substantially free of surfactant. ### Claim 20 An anti-viral composition comprising at least one low molecular weight hydrophobically modified polymers and at least one polyalkylene glycol in an amount effective to inhibit entry of viruses into cells and at least 55% water, wherein said composition is substantially free of surfactant having an HLB greater than 12. ### Claim 21 A method of inhibiting the transmission of influenza and other enveloped viruses comprising applying to non-biological surfaces a composition comprising at least one low molecular weight hydrophobically modified polymers and at least one polyalkylene glycol in an amount effective to inhibit entry of influenza viruses into cells wherein said composition is substantially free of surfactant. ### Claim 22 A method of inhibiting the transmission of influenza viruses comprising applying to ingestable surfaces a composition comprising at least one low molecular weight hydrophobically modified polymers and at least one polyalkylene glycol in an amount effective to inhibit entry of viruses into cells wherein said composition is substantially free of surfactant. ### Claim 23 (depends on 20) A composition according to claim 20 wherein said composition comprises a dosage form selected from the group consisting of: a liquid, a lotion, a cream, a gel, a stick, a spray, a shaving cream, an ointment, a cleansing liquid wash, a solid bar, a shampoo, a paste, a powder, a mousse, a wipe, a patch, a wound dressing, an adhesive bandage, a hydrogel and a film. ### Claim 24 (depends on 20) A composition according to claim 20 wherein said hydrophobically modified low molecular weight polymer comprises a low molecular weight, non-crosslinked, linear acrylic copolymer derived from at least one first monomeric component selected from the group consisting of (meth)acrylic acid and at least one second monomeric component selected from the group consisting of one or more C1 to C9 alkyl (meth)acrylates, wherein the low molecular weight copolymer has a number average molecular weight of about 100,000 or less. ### Claim 25 (depends on 24) A composition according to claim 24 wherein said hydrophobically modified low molecular weight polymer is potassium acrylates copolymer.