# US 2021/0330560 A1 · Cosmetic gel comprising a triglyceride oil

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- Number: US 2021/0330560 A1
- Document ID: US20210330560A1
- Status: Published application
- Kind: A1
- Application number: 17/279,768
- Filed: 2019-09-24
- Published: 2021-10-28
- Earliest claimed: 2018-09-26
- Assignees: Clariant International Ltd.
- Applicants: Clariant International Ltd.
- Inventors: Gerd DAHMS; Nagesh Appasaheb WAGDARE
- Web page: https://patentgrep.com/patent/US20210330560A1

## CPC

- A61K 8/066: {Multiple emulsions, e.g. water-in-oil-in-water}
- A61K 8/042: {Gels}
- A61K 8/14: Liposomes; Vesicles
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/86: Polyethers
- A61K 8/922: {of vegetable origin}
- A61Q 5/12: Preparations containing hair conditioners
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/007: {Preparations for dry skin}
- A61K 2800/21: Emulsions characterized by droplet sizes below 1 micron
- A61K 2800/87: Application Devices; Containers; Packaging
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

According to the invention, a cosmetic gel is provided comprising multilamellar vesicles dispersed in an aqueous phase, wherein the multilamellar vesicles have the shape of a rotational body comprising two or more concentric lipid double layers, the cosmetic gel comprising: a) a surfactant component, comprising at least one vesicle-forming surfactant, which is a surfactant having a HLB value of greater than 6; b) an oily phase comprising a triglyceride oil; c) an aqueous phase comprising a water-soluble polyhydric alcohol; and wherein the multilamellar vesicles have a median particle size d(50) from 50 to 800 nanometres and wherein the particle size distribution is Gaussian and the standard deviation is less than 30% of the median particle size d(50).

## Claims

### Claim 1

A cosmetic gel comprising multilamellar vesicles dispersed in an aqueous phase, wherein the multilamellar vesicles have the shape of a rotational body comprising two or more concentric lipid double layers, the cosmetic gel comprising:
a) a surfactant component, comprising at least one vesicle-forming surfactant, which is a surfactant having a HLB value of greater than 6;
b) an oily phase comprising a triglyceride oil; and
c) an aqueous phase comprising a water-soluble polyhydric alcohol;
and wherein the multilamellar vesicles have a median particle size d(50) from 50 to 800 nanometers and wherein the particle size distribution is Gaussian and the standard deviation is less than 30% of the median particle size d(50).

### Claim 2 (depends on 1)

The cosmetic gel of claim 1, comprising from 15 wt. % to 80 wt. % of triglyceride oil.

### Claim 3 (depends on 1)

The cosmetic gel of claim 1, wherein the triglyceride oil comprises coconut oil, palm kernel oil, palm stearin oil, cotton stearin oil, corn oil, soybean oil, rice oil, jojoba oil, babusscu oil, pumpkin oil, grapeseed oil, sesame oil, walnut oil, apricot oil, macadamia oil, avocado oil, sweet almond oil, lady's-smock oil, castor oil, olive oil, peanut oil, rapeseed oil, argan oil, abyssinian oil, mustard oil, sesame oil, sunflower oil, olive oil, linseed oil, neem oil, almond oil, gooseberry oil, jojoba oil, rapeseed oil, Jasmine oil, caprylic capric triglyceride or mixtures thereof.

### Claim 4 (depends on 1)

The cosmetic gel of claim 1, wherein the triglyceride oil comprises one or more triglyceride oils which have a melting point which is greater than or equal to 20 degrees Celsius.

### Claim 5 (depends on 1)

The cosmetic gel of claim 1, wherein the triglyceride oil comprises coconut oil.

### Claim 6 (depends on 1)

The cosmetic gel of claim 1, wherein the multilamellar vesicles are spherical, ellipsoidal or disk-shaped.

### Claim 7 (depends on 1)

The cosmetic gel of claim 1, wherein the standard deviation is less than 20% of the median particle size d(50).

### Claim 8 (depends on 1)

The cosmetic gel of claim 1, wherein the oily phase additionally comprises oils which are not triglyceride oils, and the cosmetic gel comprises at least 35 wt. % oily phase.

### Claim 9 (depends on 1)

The cosmetic gel of claim 1, comprising from 1 wt. % to 40 wt. % of vesicle-forming surfactant.

### Claim 10 (depends on 1)

The cosmetic gel of claim 1, wherein the surfactant component further comprises one or more co-surfactants, wherein a co-surfactant is a surfactant having a HLB value ≤6.

### Claim 11 (depends on 1)

The cosmetic gel of claim 1, wherein the weight ratio of oily phase to surfactant component is 80:0.1 to 80:30.

### Claim 12 (depends on 1)

The cosmetic gel of claim 1, wherein the lamellar vesicles comprise vesicle-forming surfactant and triglyceride oil and, if present, co-surfactant and/or oils, which are not triglyceride oils, and wherein the packing parameter of the mixture of these components has a value of 0.5 or above.

### Claim 13 (depends on 1)

The cosmetic gel of claim 1, comprising at least 1 wt. % aqueous phase.

### Claim 14 (depends on 1)

The cosmetic gel according to claim 1, comprising from 1 wt. % to 15 wt. % of water soluble polyhydric alcohol.

### Claim 15 (depends on 1)

The cosmetic gel according to claim 1, wherein the water soluble polyhydric alcohol comprises 1,2-propylene glycol, 1,3-propylene glycol, glycerine or mixtures thereof.

### Claim 16 (depends on 1)

The cosmetic gel of claim 1, comprising a polymeric amphiphilic component selected from the group consisting of polyvinyl acetate, polyvinyl pyrrolidone, polyvinyl alcohols, vinyl pyrrolidone (VP)/hexadecene copolymer, VP/eicosene copolymer, silicone oils and their derivatives, and mixtures thereof.

### Claim 17 (depends on 1)

The cosmetic gel of claim 1, wherein the cosmetic gel is a leave-on cosmetic composition for conditioning skin or keratinous material.

### Claim 18 (depends on 1)

A cosmetic product comprising a packaging having a reservoir containing the cosmetic gel of claim 1 and a dispensing opening in fluid communication with the reservoir for dispensing the cosmetic gel.

### Claim 19 (depends on 18)

The cosmetic product of claim 18, wherein the packaging comprises a pump dispenser for pumping cosmetic gel from the reservoir to the dispensing opening.

### Claim 20 (depends on 18)

The cosmetic product of claim 18, wherein the packaging is configured as an aerosol dispenser.

### Claim 21

A process for skin conditioning or moisturization or for hair conditioning comprising the step of contacting the skin or hair with a composition comprising at least one cosmetic gel comprising multilamellar vesicles dispersed in an aqueous phase, wherein the multilamellar vesicles have the shape of a rotational body comprising two or more concentric lipid double layers, the cosmetic gel comprising:
a) a surfactant component, comprising at least one vesicle-forming surfactant, which is a surfactant having a HLB value of greater than 6;
b) an oily phase comprising a triglyceride oil; and
c) an aqueous phase comprising a water-soluble polyhydric alcohol;
and wherein the multilamellar vesicles have a median particle size d(50) from 50 to 800 nanometers and wherein the particle size distribution is Gaussian and the standard deviation is less than 30% of the median particle size d(50).

### Claim 22

A process of making a cosmetic gel comprising multilamellar vesicles dispersed in an aqueous phase, wherein the multilamellar vesicles have the shape of a rotational body comprising two or more concentric lipid double layers, the cosmetic gel comprising:
a) a surfactant component, comprising at least one vesicle-forming surfactant, which is a surfactant having a HLB value of greater than 6;
b) an oily phase comprising a triglyceride oil; and
c) an aqueous phase comprising a water-soluble polyhydric alcohol;
and wherein the multilamellar vesicles have a median particle size d(50) from 50 to 800 nanometers and wherein the particle size distribution is Gaussian and the standard deviation is less than 30% of the median particle size d(50), comprising the steps of:
a) providing a first phase comprising aqueous phase and the surfactant component;
b) providing a second phase comprising the oily phase comprising the triglyceride oil and, optionally a co-surfactant;
c) heating the first phase to a temperature from 20° C. to 60° C.;
d) introducing the second phase into the first phase while heating to a temperature from 50° C. to 90° C.;
e) mixing the combined phases; and
f) forming the cosmetic gel.

### Claim 23 (depends on 22)

The process of claim 22 further comprising the step of:
g) combining the formed cosmetic gel with additional aqueous phase.

### Claim 24 (depends on 22)

The process of claim 22, further comprising the steps of:
i. providing an emulsification device having a first inlet line in fluid communication with a turbulent mixing zone and a second inlet line in fluid communication with the turbulent mixing zone, a laminar zone in fluid communication with the turbulent mixing zone and an outlet line in fluid communication with the laminar zone;
ii. feeding the first phase into the first inlet line;
iii. feeding the second phase into the second inlet line;
iv. introducing the second phase into the first phase in the turbulent mixing zone and subjecting the phases to turbulent mixing;
v. transporting the mixed phases from the turbulent mixing zone into the laminar zone in which laminar flow of the mixed phases is established and vesicles form; and
vi. discharging the mixed phases comprising vesicles from the laminar zone of the emulsification device via the outlet line.