# US 2021/0330253 A1 · Geospatial bioimpedance biosurveillance tool

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- Number: US 2021/0330253 A1
- Document ID: US20210330253A1
- Status: Published application
- Kind: A1
- Application number: 17/240,509
- Filed: 2021-04-26
- Published: 2021-10-28
- Earliest claimed: 2020-04-28
- Inventors: Wayne C. A. Wright; John D. Kutzko
- Web page: https://patentgrep.com/patent/US20210330253A1

## CPC

- A61B 5/4842: {Monitoring progression or stage of a disease}
- A61B 5/0004: {characterised by the type of physiological signal transmitted}
- A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet}
- A61B 5/0537: Measuring body composition by impedance, e.g. tissue hydration or fat content
- A61B 5/1112: {Global tracking of patients, e.g. by using GPS}
- A61B 5/256: Wearable electrodes, e.g. having straps or bands
- A61B 5/257: using adhesive means, e.g. adhesive pads or tapes
- A61B 5/445: {Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore}
- A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)}
- A61B 5/4875: {Hydration status, fluid retention of the body}
- A61B 5/4881: {Determining interstitial fluid distribution or content within body tissue (measuring analytes in interstitial fluid in-vivo A61B5/1451)}
- A61B 5/6806: {Gloves}
- A61B 5/6826: {Finger}
- A61B 5/6829: {Foot or ankle}
- A61B 5/6831: {Straps, bands or harnesses}
- A61B 5/6833: {Adhesive patches}
- A61B 5/742: {using visual displays (displays for heart-related electrical signals, e.g. ECG, A61B5/339)}
- A61B 5/746: {Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms}
- A61B 5/265: containing silver or silver chloride
- Y02A 90/10: Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

A health care management system for geospatial biosurveillance including a bioimpedance device. The health care management system provides real time data and analysis of an individual's physiological condition using bioimpedance data. The health care management system is further operable to monitor and model disease progression and remission based on physiological conditions during a pandemic event as well as modeling the treatment and remediation of long-lasting physiological symptoms and organ damage due to post-acute sequelae of SARS-CoV2 infection (PASC).

## Claims

### Claim 1

A system for continuous or near continuous impedance monitoring of a user comprising:
at least two electrodes;
at least one bioelectric impedance device including a power source and a current detection component; and
at least one remote device including an analytics platform;
wherein the at least one bioelectric impedance device is in network communication with the at least one remote device;
wherein the at least two electrodes are in contact with the user;
wherein at least one electrode of the at least two electrodes bisects the ulnar styloid process of the user and at least one different electrode of the at least two electrodes is positioned on the distal phalanx of the middle finger of the user;
wherein the at least one bioelectric impedance device is configured to generate current between the at least two electrodes via a wired connection or a wireless connection;
wherein the at least one bioelectric impedance device is configured to capture impedance data of the user based on a voltage difference between the at least two electrodes, wherein the impedance data includes resistance data and reactance data;
wherein the at least one remote device is configured to receive the impedance data from the at least one bioelectric impedance device, and wherein the at least one remote device is configured to generate phase angle data based on the impedance data;
wherein the at least one remote device is configured to generate health status data based on the impedance data and phase angle data;
wherein the at least one remote device is configured to determine if the user is affected by a disease based on the impedance data and the phase angle data; and
wherein the at least one remote device is configured to monitor a progression of the disease based on the impedance data and the phase angle data.

### Claim 2

(canceled)

### Claim 3

(canceled)

### Claim 4 (depends on 1)

The system of claim 1, wherein the at least two electrodes are configured for wireless charging, wherein the at least two electrodes are configured to receive an energization signal from the at least one remote device.

### Claim 5 (depends on 1)

The system of claim 1, wherein the at least one remote device includes a display, wherein the at least one remote device is configured to track the location of the user via the at least one bioelectric impedance device, wherein the at least one remote device is configured to display the location and health status of the user.

### Claim 6

(canceled)

### Claim 7 (depends on 1)

The system of claim 1, wherein the system is further configured to identify when the user is affected by a disease, wherein the disease includes at least one of COVID-19, endocannabinoid system deficiency, cachexia, malnutrition, oncologic diseases, HIV infection, AIDS, HCV, viral, bacterial, fungal, and parasitic infections, cholera, diabetes mellitus, congestive heart failure, multiple sclerosis, rheumatoid arthritis, obesity, lymphedema, liver cirrhosis, chronic obstructive pulmonary disease, hemodialysis, inflammation, cytokine storm syndrome, organ failure, Parkinson's disease, migraines and/or sepsis.

### Claim 8

(canceled)

### Claim 9

(canceled)

### Claim 10

(canceled)

### Claim 11

(canceled)

### Claim 12

(canceled)

### Claim 13

(canceled)

### Claim 14

(canceled)

### Claim 15

(canceled)

### Claim 16

(canceled)

### Claim 17

(canceled)

### Claim 18

A system for continuous or near continuous impedance monitoring of a plurality of users comprising:
a bioelectric impedance device;
at least one remote device; and
at least one remote server including an analytics platform;
wherein the bioelectric impedance device is positioned on each user of the plurality of users;
wherein the bioelectric impedance device, the at least one remote device, and the at least one remote server are in network communication;
wherein the bioelectric impedance device is configured to capture impedance data for the plurality of users, wherein the impedance data includes resistance data and reactance data;
wherein the at least one remote device is configured to generate phase angle data based on the impedance data;
wherein the at least one remote device is configured to determine if each user of the plurality of users is suffering from a disease;
wherein the at least one remote server is configured to store historical data; wherein the historical data includes medical historical data and nutritional historical data of the plurality of users;
wherein the analytics platform is configured to generate a baseline physiological condition for each user of the plurality of users;
wherein the at least one remote device is configured to determine the tissue hydration status of at least one user of the plurality of users based on the impedance data and the phase angle data;
wherein the at least one remote device is configured to monitor a progression of the disease for each user of the plurality of users based on the impedance data and the phase angle data; and
wherein the at least one remote server is configured to generate an alert when a physiological condition of at least one user of the plurality of users exceeds at least one threshold from the baseline physiological condition of the at least one user of the plurality of users.

### Claim 19

(canceled)

### Claim 20 (depends on 18)

The system of claim 18, wherein the at least one remote device is configured to determine fluid volume, cell mass, and cell membrane integrity of the at least one user of the plurality of users based on the impedance data, wherein the analytics platform is configured to track the changes in the fluid volume, cell mass, and cell membrane integrity of the at least one user of the plurality of users over time, wherein the analytics platform is further configured to correlate the changes in the fluid volume, cell mass, and cell membrane integrity of the at least one user of the plurality of users with the progression of the disease.

### Claim 21

A system for continuous or near continuous impedance monitoring of a user comprising:
at least two electrodes;
at least one bioelectric impedance device including a power source and a current detection component; and
at least one remote device including an analytics platform;
wherein the at least one bioelectric impedance device is in network communication with the at least one remote device;
wherein the at least two electrodes are in contact with the user;
wherein the at least two electrodes include at least one signal detection electrode and at least one signal induction electrode, wherein the at least one signal detection electrode bisects the medial malleolus of the user and the at least one signal induction electrode is positioned on the hallux of the user;
wherein the at least one bioelectric impedance device is configured to generate current between the at least two electrodes via a wired connection or a wireless connection;
wherein the at least one bioelectric impedance device is configured to capture impedance data of the user based on a voltage difference between the at least two electrodes, wherein the impedance data includes resistance data and reactance data;
wherein the at least one remote device is configured to receive the impedance data from the at least one bioelectric impedance device, and wherein the at least one remote device is configured to generate phase angle data based on the impedance data;
wherein the at least one remote device is configured to generate health status data based on the impedance data and phase angle data;
wherein the at least one remote device is configured to determine if the user is affected by a disease based on the impedance data and the phase angle data; and
wherein the at least one remote device is configured to monitor the progression of the disease based on the impedance data and the phase angle data.

### Claim 22 (depends on 21)

The system of claim 21, further including a remote server including an artificial intelligence component, wherein the artificial intelligence component is configured to provide at least one recommendation for the user, wherein the at least one recommendation includes at least one time and at least one location to provide medical assistance.

### Claim 23 (depends on 21)

The system of claim 21, further including a remote server including an artificial intelligence component, wherein the artificial intelligence component is configured to generate a physiological condition for the user, wherein the artificial intelligence component is configured to provide at least one alert when the physiological condition of the user is demonstrating signs of illness and/or disease, wherein the at least one alert is transmitted to the at least one remote device.

### Claim 24 (depends on 21)

The system of claim 21, wherein the at least one bioelectric impedance device includes at least one of a glove, a band, or a patch, wherein the at least one bioelectric impedance device further includes at least one body sensor.

### Claim 25 (depends on 21)

The system of claim 21, wherein the at least one remote device is configured to determine at least one body parameter of the user, wherein the at least one body parameter includes body cell mass, fat free mass, fat mass, nutrition status, fitness level, extracellular mass, water retention, and/or total body water.

### Claim 26 (depends on 21)

The system of claim 21, wherein the at least one remote device is further configured to identify when the user is affected by a disease, wherein the disease includes at least one of COVID-19, post-acute COVID-19 syndrome, cachexia, endocannabinoid system deficiency, malnutrition, oncologic diseases, Human Immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS), Hepatitis C (HCV), viral, bacterial, fungal, and parasitic infections, cholera, diabetes mellitus, congestive heart failure, multiple sclerosis, rheumatoid arthritis, obesity, lymphedema, liver cirrhosis, chronic obstructive pulmonary disease, hemodialysis, Parkinson's disease, organ failure, migraines, and/or sepsis.

### Claim 27 (depends on 21)

The system of claim 21, further including at least one remote server including an artificial intelligence component, wherein the at least one remote server is configured to receive third-party data from at least one third-party data source via network communication, wherein the at least one remote server is configured to generate a health care plan in response to the impedance data and the third-party data.

### Claim 28 (depends on 21)

The system of claim 21, further including at least one remote server including an artificial intelligence component, wherein the at least one remote server is configured to receive the impedance data, the phase angle data, and the health status data for the user, wherein the artificial intelligence component is configured to determine and model trends between the impedance data, the phase angle data, and the health status data prior to the user being affected by the disease, during the progression of the disease, and during recovery.

### Claim 29 (depends on 21)

The system of claim 21, wherein the at least one remote device is configured to detect antibodies based on the impedance data for the user.

### Claim 30 (depends on 21)

The system of claim 21, wherein the at least one remote device is configured to track the geolocation of the user via the at least one bioelectric impedance device, wherein the at least one remote device includes a display, and wherein the at least one remote device is configured to create a map using the geolocation of the user, wherein the at least one remote device is configured to color code the user based on the health status data, wherein the health status data includes nutrition data and hydration data.

### Claim 31 (depends on 18)

The system of claim 18, wherein the at least one remote device is configured to determine at least one body parameter of each user of the plurality of users, wherein the at least one body parameter includes body cell mass, fat free mass, fat mass, nutrition status, fitness level, extracellular mass, water retention, and/or total body water.

### Claim 32 (depends on 18)

The system of claim 18, wherein the at least one remote device is configured to detect antibodies based on the impedance data for each user of the plurality of users, wherein the analytics platform is further configured to model herd immunity based on the detection of antibodies for each user of the plurality of users.

### Claim 33 (depends on 18)

The system of claim 18, wherein the at least one remote device is configured to track the geolocation of the plurality of users via the bioelectric impedance device, wherein the at least one remote device includes a display, and wherein the at least one remote device is configured to create a map using the geolocation of the plurality of users, wherein the at least one remote device is configured to color code each user of the plurality of users based on the health status data, wherein the health status data includes nutrition data and hydration data.

### Claim 34 (depends on 18)

The system of claim 18, wherein the at least two electrodes are placed on opposite sides of a wound, wherein the impedance data includes directional changes of the resistance data, wherein the system is configured for longitudinal monitoring of the directional changes of the resistance data, wherein the at least one remote device is configured to determine the status of the wound based on the changes in the resistance data.
