# US 2021/0329916 A1 · Stable co-formulation of benzoylurea with pyrethroids > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0329916 A1 - Document ID: US20210329916A1 - Status: Published application - Kind: A1 - Application number: 17/251,579 - Filed: 2019-06-04 - Published: 2021-10-28 - Earliest claimed: 2018-06-18 - Assignees: Upl Ltd - Applicants: Upl Ltd - Inventors: Pravin Namadeo More; Rajan Ramakant Shirsat; Jaidev Rajnikant Shroff; Vikram Rajnikant Shroff - Web page: https://patentgrep.com/patent/US20210329916A1 ## CPC - A01N 25/28: Microcapsules {or nanocapsules} - A01N 47/34: containing the groups [IMAGE cpc-sch-A01N-0947.gif], e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products - A01N 53/00: Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof - A01P 7/00: Arthropodicides - B01J 13/14: Polymerisation; cross-linking - B01J 13/16: Interfacial polymerisation - Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS - Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ## Abstract The present invention provides a microencapsulated formulation comprising a pyrethroid insecticide solubilized in vegetable oil or derivatives thereof, the solubilized pyrethroid insecticide being encapsulated in a capsule having a polymeric shell wall. The invention also provides a process of preparing said microencapsulated formulation. The invention further provides a co-formulation comprises microencapsulated formulation of pyrethroid and a suspension concentrate comprising benzoylurea insecticide. ## Claims ### Claim 1 A microencapsulated formulation comprising a pyrethroid insecticide solubilized in a vegetable oil, wherein the solubilized pyrethroid insecticide is encapsulated in a capsule having a polymeric shell wall. ### Claim 2 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein the pyrethroid insecticide is selected from the group consisting of cyhalothrin, lambdacyhalothrin, bifenthrin, allethrin, cypermethrin, dimethrin, fenvalerate, permethrin, alphacypermethrin, betacypermethrin, zetacypermethrin, deltamethrin, cyfluthrin, bioresmethrin, phenothrin, biopermethrin, decamethrin, fluvalinate, barthrin, and mixtures thereof. ### Claim 3 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein pyrethroid insecticide is lambdacyhalothrin. ### Claim 4 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein the vegetable oil is selected from the group consisting of olive oil, kapok oil, castor oil, papaya oil, camellia oil, palm oil, sesame oil, corn oil, rice bran oil, peanut oil, cotton seed oil, soybean oil, rapeseed oil, linseed oil, tung oil, sunflower oil, safflower oil, tall oil, an alkyl ester of a vegetable oils, and combinations thereof. ### Claim 5 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein the vegetable oil is selected from the group consisting of olive oil, castor oil, palm oil, sesame oil, rice bran oil, peanut oil, cotton seed oil, soybean oil, rapeseed oil, linseed oil, tung oil, sunflower oil, safflower oil, and tall oil. ### Claim 6 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein the capsule having a polymeric shell wall is made by an interfacial polymerization reaction occurring between an organic phase emulsified in an aqueous phase. ### Claim 7 (depends on 6) The microencapsulated formulation as claimed in claim 6, wherein the organic phase of said interfacial polymerization for capsule formations comprises the pyrethroid insecticide, vegetable oil and an isocyanate. ### Claim 8 (depends on 6) The microencapsulated formulation as claimed in claim 6, wherein the aqueous phase of said interfacial polymerization for capsule formations comprises a protective colloid and water. ### Claim 9 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein the polymeric shell wall of the capsule comprises polyurea and polyurethane. ### Claim 10 (depends on 1) A process of preparing the microencapsulated formulation of claim 1 wherein said process comprises: a. preparing an organic phase comprising the pyrethroid insecticide solubilized in the vegetable oil or derivatives thereof, and at least one isocyanate; b. preparing an aqueous phase comprising water, a protective colloid and at least one aliphatic diol; c. mixing the aqueous and organic phases to form an oil in water emulsion; and d. adding at least one polyamine to said oil-in-water emulsion to trigger an interfacial condensation between said at least one isocyanate in the organic phase with the polyamine and/or aliphatic diol in the aqueous phase to form the polymeric shell wall. ### Claim 11 (depends on 10) The process of encapsulation of pyrethroid insecticide as claimed in claim 10, wherein at least one aliphatic diol is added prior to emulsification. ### Claim 12 A process of encapsulation of lambdacyhalothrin, said process comprising: a. preparing an organic phase comprising a lambdacyhalothrin solubilized in soybean oil, and polymethylene polyphenylisocyanate; b. preparing an aqueous phase comprising water and monopropylene glycol; c. mixing the aqueous and organic phases to form an oil in water emulsion; and d. adding ethylene diamine and diethylenetriamine to said oil-in-water emulsion to trigger an interfacial condensation between said polymethylene polyphenylisocyanate in the organic phase with the ethylene diamine, diethylenetriamine and/or monopropylene glycol in the aqueous phase to form a polymeric shell wall. ### Claim 13 A co-formulation comprising: (a) a microencapsulated formulation comprising a pyrethroid insecticide solubilized in a vegetable oil or derivatives thereof, wherein the solubilized pyrethroid insecticide is encapsulated in a capsule having a polymeric shell wall; and (b) a suspension concentrate comprising at least one benzoylurea insecticide. ### Claim 14 (depends on 13) The co-formulation as claimed in claim 13, wherein the pyrethroid insecticide comprises lambdacyhalothrin, the vegetable oil comprises soybean oil, and the benzoylurea insecticide comprises novaluron. ### Claim 15 (depends on 13) A process for preparation of the co-formulation of claim 13, said process comprising: a. preparing the microencapsulated pyrethroid formulation; b. preparing the benzoylurea suspension concentrate formulation; and c. preparing the co-formulation of benzoylurea and pyrethroid by mixing the suspension concentrate of benzoylurea and the microencapsulated pyrethroid formulation. ### Claim 16 (depends on 15) The process for preparation of the co-formulation as claimed in claim 15, wherein the pyrethroid is lambdacyhalothrin and the benzoylurea is novaluron. ### Claim 17 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein the pyrethroid insecticide is released at a rapid rate and reaches a highest point of release by 10-12 hours. ### Claim 18 (depends on 1) The microencapsulated formulation as claimed in claim 1, wherein the pH of the formulation is in the range of 5.0-6.5. ### Claim 19 (depends on 13) A method of controlling or preventing unwanted pests, said method comprising, applying an effective amount of the co-formulation according to claim 13, to the pests or to their locus. ### Claim 20 (depends on 19) The method of controlling or preventing unwanted pests as claimed in claim 19 wherein said pests are in professional, domestic, public hygiene, or agricultural location. ### Claim 21 (depends on 19) The method of controlling or preventing unwanted pests as claimed in claim 19, wherein said insect pests belong to a class selected from the group consisting of Lepidoptera, Arachnida, Hemiptera, Bilateria, Hymenoptera, Coleoptera, Diptera, Anoplura and Hymenoptera. ### Claim 22 (depends on 19) The method of controlling or preventing unwanted pests as claimed in claim 19, wherein said co-formulation has insecticidal, nematicidal, acaricidal or molluscicidal activity.