US 2021/0325378 A1Published application

Methods and compositions for removing biotin interference from assays using cyclodextrin traps

AssigneeSiemens Healthcare Diagnostics Inc.

InventorTie WEI

Life of this patent

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The present invention relates to methods and compositions to remove or reduce biotin interference from certain assays.

Dependent claims

A molecular trap to reduce free-hapten interference in an assay, the molecular trap comprising:

a molecular cage that comprises a shell that surrounds a cavity having characteristics to selectively capture and retain a hapten that is unconjugated or free in an assay solution, the shell of the molecular cage being selected from the group consisting of a cyclodextrin shell and a molecular-imprint-specific binding partner shell for the hapten.

Dependencies are inferred from the claim text.

G01N 33/5306
Immunoassay; Biospecific binding assay; Materials therefor: improving reaction conditions, e.g. reduction of non-specific binding, promotion of…
C07K 16/44
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material not provided for elsewhere , e.g. haptens, metals, DNA, RNA,…
G01N 1/34
Preparing specimens for investigation including physical details of chemical methods covered elsewhere, e.g. G01N33/50, C12Q: purifying; Cleaning
G01N 33/543
Immunoassay; Biospecific binding assay; Materials therefor: with an insoluble carrier for immobilising immunochemicals

From the US filing history. Foreign family members aren’t listed.

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