Lint Free Crosslinked Chitosan-PVA Sponge as an Absorbent Wound Dressing and Method of Preparation Thereof
AssigneeSree Chitra Tirunal Institute for Medical Sciences and Technology
InventorsLynda Velutheril Thomas, Prabha Damodaran Nair, Nimi Nirmala, Shanti Krishna Ayilliath
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Abstract
This invention relates to a lint free absorbent wound dressing, comprising a plasticized blend of a natural biopolymer and poly vinyl alcohol mixed in an acidic solvent which is neutralized and crosslinked using green crosslinking buffer system, finding application in exudating and bleeding wounds.
Claims14
A lint free absorbent wound dressing, comprising a plasticized blend of a natural biopolymer and polyvinyl alcohol mixed in an acidic solvent which is neutralized and crosslinked using green crosslinking buffer system, finding application in exudating and bleeding wounds.
A process for the preparation of the wound dressing as claimed in claim comprising the steps of
- preparing an aqueous solution of polyvinyl alcohol (PVA) and preparing a solution of a biopolymer in acid/water mixture, followed by mixing the PVA solution with the biopolymer solution to obtain a blend,
- adding a plasticizer to the blend followed by adding a crosslinking agent and thoroughly mixing the same to obtain a final solution,
- subjecting said final solution to lyophilization,
- wherein lyophilization involves a step of freezing followed by a step of drying the blend, said step of freezing at a temperature in the range of −20° C. to −30° C. and the drying phase ramped up to a temperature of 35° C. with the whole lyophilization cycle ranging from 24 to 45 hours based on the feed volume to obtain cellular structured dressings.
Dependencies are inferred from the claim text.