Methods for treating aortic aneurysm disease
AssigneesThe Trustees of the University of Pennsylvania, Yale University
InventorPrashanth Vallabhajosyula
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Abstract
This present disclosure relates to the use of one or more biomarkers for diagnosis, screening, or monitoring aortic aneurysm disease (e.g., ascending aortic aneurysm, descending thoracic aortic aneurysm, abdominal aortic aneurysm and Marfan syndrome) in a biological sample (e.g., a blood sample) of a subject. Accordingly, this disclosure provides methods and kits for determining the presence of one or more biomarkers for aortic aneurysm disease in a biological sample of a subject; methods for using the presence of such biomarkers to predict or diagnose aortic aneurysm disease in a subject; and methods to select or modify a therapeutic regimen (e.g., a beta-blocker treatment) for a subject based on the use of such biomarkers.
Claims19
A method for treating a subject with aneurysm, comprising:
- (a) measuring, in a fraction of a biological sample from a subject, at least one biomarker;
- and
- (b) administering an effective amount of an aneurysm inhibitor to the subject, when the at least one biomarker is reduced compared to a reference sample.
A kit for diagnosing and/or monitoring a subject with an aortic aneurysm, comprising reagents for detecting a marker specific for an endothelial cell-derived microvesicle.
Dependencies are inferred from the claim text.