Sequencing controls
AssigneeGarvan Institute of Medical Research
InventorTimothy MERCER
Life of this patent
Estimating the term…
Abstract
The present disclosure generally relates to artificial controls for genetic sequencing and quantitation assays, which can be used to calibrate a wide variety of genetic sequencing and quantitation methods. For example, the controls disclosed herein can be used to calibrate a wide variety of high throughput sequencing methods (for example, those referred to as next generation sequencing methods). The present disclosure also generally relates to the use of the sequencing controls in a wide variety of applications including, for example, in the calibration of a wide variety of sequencing methods.
Claims19
An artificial chromosome comprising an artificial polynucleotide sequence, wherein any fragment of the artificial polynucleotide sequence is distinguishable from any known naturally occurring genomic sequence and wherein:
- i) the artificial polynucleotide sequence comprises any one or more features of naturally occurring eukaryotic chromosomes selected from the group consisting of gene loci, introns, exons, CpG islands, mobile elements, repetitive polynucleotide features, small scale genetic variation and large scale genetic variation;
- or
- ii) the artificial polynucleotide sequence comprises one or more features of naturally occurring prokaryotic chromosomes;
- or
- iii) the artificial polynucleotide sequence comprises one or more features of naturally occurring viruses, phages or organelle sequences.
Dependencies are inferred from the claim text.