Formulations of immunoglobulin a
AssigneeVentria Bioscience
InventorsSolomon Okbazghi, Vladimir Akoyev, Saurav Misra, Randall Alfano
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Abstract
Stabilized formulations for Immunoglobulin A and other biotherapeutic proteins. Formulations comprising at least one pH buffering agent at about pH 5 to about 8, optional non-ionic surfactant, and one or more optional stabilizing agents selected from the group consisting of amino acids, sugars/polyols, chloride salts, carboxylic acids, detergents, natural proteins, protein expression extracts, and mixtures thereof.
Claims37
A stabilized prophylactic and/or therapeutic formulation comprising a therapeutically-effective amount of immunoglobulin A (IgA) dispersed in a pH buffering agent at a pH of from about 5 to about 8, wherein said formulation further comprises an optional non-ionic surfactant and one or more optional stabilizing agents, wherein said formulation exhibits physical and chemical stability after mechanical agitation and/or a freeze/thaw cycle.
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Dependencies are inferred from the claim text.