Novel aminophosphinic derivatives as aminopeptidase a inhibitors
AssigneesQuantum Genomics, Institut National de la Sante et de la Recherche Medicale, Centre National De La Recherche Scientifique, College De France
InventorsFABRICE BALAVOINE, DELPHINE COMPERE, CATHERINE LLORENS-CORTES
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Abstract
The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
Claims10
1-9. (canceled)
A compound having the following formula (I):
- or formula (II):
- wherein:
- AH represents —CO2H, —SO3H, —PO3H2;
- I is 2 or 3;
- m is 0,1, 2 or 3;
- R1 represents a halogen atom, an alkyl group, a haloalkyl group, an alkoxy group, a haloalkoxy group, an O-cycloalkyl group, an O-aryl group, an O-arylalkyl group, a heteroalkyl group, an amino group optionally mono or disubstituted by an alkyl group, an haloalkyl a haloalkyl group, a cycloalkyl group, an acyl group, an aryl group or an arylalkyl group;
- R2 and R3 represent independently a hydrogen atom, a halogen atom, an alkyl group, a haloalkyl group or can form together with the adjacent carbon atom depicted in formula (I) or (II) a cycloalkyl group;
- a pharmaceutical salt, solvate, zwitterionic form or prodrug thereof.
A compound having the following formula (III):
- or formula (IV):
- wherein:
- I is 2 or 3;
- m is 0,1, 2 or 3;
- R1 represents a halogen atom, an alkyl group, a haloalkyl group, an alkoxy group, a haloalkoxy group, an O-cycloalkyl group, an O-aryl group, an O-arylalkyl group, a heteroalkyl group, an amino group optionally mono or disubstituted by an alkyl group, a haloalkyl group, a cycloalkyl group, an acyl group, an aryl group or an arylalkyl group;
- R2 and R3 represent independently a hydrogen atom, a halogen atom, an alkyl group, a haloalkyl group or can form together with the adjacent carbon atom depicted in formula (I) or (II) a cycloalkyl group;
- A represents —SO3Z —CO2Z or —P(O)(OZ)2, with Z selected from the group consisting of a hydrogen atom, an alkyl and arylalkyl group;
- X represents a hydrogen atom, —(CO)-alkyl, —(CO)-alkoxy, —(CO)-benzyloxy,
- wherein R represents an alkyl group and, R′ and R″ represent independently a hydrogen atom or an alkyl group;
- Y represents a hydrogen atom, an alkyl, aryl, arylalkyl or
- wherein R represents an alkyl group and, R′ and R″ represent independently a hydrogen atom or an alkyl group,
- wherein at least one of Z, X and Y is different from a hydrogen atom.
15-17. (canceled)
Dependencies are inferred from the claim text.