Oxygen-generating cryogels
AssigneeNortheastern University Center for Research Innovation, Northeastern Univ.
InventorsAdnan Memic, Sidi A. Bencherif, Michail Sitkovsky, Thibault Colombani, Stephen Hatfield
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Abstract
Disclosed are nanocomposite oxygen-generating cryogels and their uses in reducing hypoxia in a biological tissue, such as a tumor. Methods of treating cancer with the disclosed cryogels are also provided.
Claims29
A method of reducing hypoxia in a biological tissue, comprising administering to the biological tissue an oxygen-generating cryogel, wherein the administration is by injection, catheter, or surgery.
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A method of treating cancer, comprising administering into a tumor of a mammal an effective amount of an oxygen-generating cryogel;
- wherein the administration is by injection, catheter or surgery;
- and the cryogel comprises polymerized hyaluronic acid glycidyl methacrylate, acrylate-PEG-G4RDGSP, acrylate-PEG-Catalase, and CaO2.
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Dependencies are inferred from the claim text.