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US 2021/0301302 A1Published application
A novel drug delivery system and methods providing thereof
AssigneeNEUWAY Pharma GmbH
InventorsVictoria DEMINA, Heiko MANNINGA, Sergey SOTNIKOV, Marcus STAPF, Katja Janina KOßMANN
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Abstract
The invention relates to a method for providing a drug delivery system, in particular for crossing the blood brain barrier (BBB), comprising a virus-like particle (VLP) derived from John Cunningham virus (JCV), a drug delivery system and novel VLP obtainable by said method. The method comprises steps of disassembly of VLP into pentamers and reassembly into VLP.
Claims15
1-51. (canceled)
Method for providing a drug delivery system comprising a virus-like particle (VLP) derived from John Cunningham virus (JCV) comprising the following steps:
- a) providing a composition comprising VP1 proteins,
- b) exposing the VP1 proteins of the composition of a) to conditions inducing the VP1 to assemble into VLP,
- c) exposing the VLP of the composition of b) to conditions disassembling the VLP into pentamers,
- d) exposing the pentamers of the composition of c) to conditions inducing the pentamers to reassemble into VLP
- e) exposing the VLP of the composition of d) to conditions disassembling the VLP into pentamers,
- f) exposing the pentamers of the composition of e) to a cargo and conditions inducing the pentamers to assemble into a VLP associated with the cargo.
3 more elements
Dependencies are inferred from the claim text.