Porous body and material for medical use

18:

• A porous body which has a first surface and a second surface, and which comprises a first polymer material and a second polymer material, wherein
• a Young's modulus of the porous body determined based on tensile strength in water, in purified water at 37° C., is 0.1 MPa or higher and 10 MPa or lower,
• (i) a mass loss rate of a first sample, when the first sample that is collected from a first region of the porous body and that has a size of 10 mm×10 mm is immersed in a simulated biological fluid at 35° C. to 39° C. for 30 days, is higher than (ii) a mass loss rate of a second sample, when the second sample that is collected from a second region of the porous body and that has a size of 10 mm×10 mm is immersed in a simulated biological fluid at 35° C. to 39° C. for 30 days,
• a distance between the first region and the first surface is shorter than a distance between the second region and the first surface,
• the first polymer material is a material having higher biodegradability or bioabsorbability than the second polymer material, and
• the second polymer material comprises at least one selected from a group consisting of (i) chitin, sericin, fibroin, carboxymethyl cellulose, and chitosan, and (ii) salts and derivatives of these.

19:

• A porous body which has a first surface and a second surface, and which comprises a first polymer material and a second polymer material, wherein
• a Young's modulus of the first polymer material is lower than a Young's modulus of the second polymer material,
• an in vivo disappearance rate of the first polymer material is higher than an in vivo disappearance rate of the second polymer material,
• a composition of the porous body in a first region and a composition of the porous body in a second region are different from each other,
• a distance between the first region and the first surface is shorter than a distance between the second region and the first surface, and
• the second polymer material comprises at least one selected from a group consisting of (i) chitin, sericin, fibroin, carboxymethyl cellulose, and chitosan, and (ii) salts and derivatives of these.

20:

• A porous body which has a first surface and a second surface, and which comprises a first polymer material and a second polymer material, wherein
• a Young's modulus of the first polymer material is lower than a Young's modulus of the second polymer material,
• absorbability of the first polymer material with respect to phosphate buffered saline is greater than absorbability of the second polymer material with respect to phosphate buffered saline,
• a composition of the porous body in a first region and a composition of the porous body in a second region are different from each other,
• a distance between the first region and the first surface is shorter than a distance between the second region and the first surface, and
• the second polymer material comprises at least one selected from a group consisting of (i) chitin, sericin, fibroin, carboxymethyl cellulose, and chitosan, and (ii) salts and derivatives of these.

23:

• The porous body according to claim 18, comprising:
• a first surface layer that is porous and is arranged on a surface of the porous body on a first surface side;
• and
• a support layer that is porous and is arranged on a second surface side of the first surface layer to support the first surface layer, wherein
• the first region is arranged on at least a part of the first surface layer, and
• the second region is arranged on at least a part of the support layer.

25:

• The porous body according to claim 23, wherein
• each of the first surface layer and the support layer has a web of a composite fiber that comprises the first polymer material and the second polymer material,
• the composite fiber has a core-shell structure including a core of the second polymer material and a shell of the first polymer material, and
• (i) a ratio of a diameter or equivalent diameter of the core to a diameter or equivalent diameter of the shell in the composite fiber of the first region is smaller than (ii) a ratio of a diameter or equivalent diameter of the core to a diameter or equivalent diameter of the shell in the composite fiber of the second region.

26:

• The porous body according to claim 23, wherein
• (c) a ratio of a density of the second polymer material to a density of the first polymer material in a third region of the porous body, and (b) the ratio of the density of the second polymer material to the density of the first polymer material in the second region of the porous body are different from each other,
• a distance between the third region and the first surface is shorter than the distance between the second region and the first surface, and
• the third region is arranged on at least a part of the support layer.

28:

• The porous body according to claim 27, wherein
• (a) a ratio of a density of the second polymer material to a density of the first polymer material in the first region of the porous body is smaller than (b) a ratio of a density of the second polymer material to a density of the first polymer material in the second region of the porous body,
• (d) a ratio of a density of the second polymer material to a density of the first polymer material in a fourth region of the porous body is smaller than (b) the ratio of the density of the second polymer material to the density of the first polymer material in the second region of the porous body,
• a distance between the fourth region and the first surface is longer than the distance between the second region and the first surface, and
• the fourth region is arranged on at least a part of the second surface layer.

29:

• The porous body according to claim 18, wherein
• the first polymer material comprises at least one substance selected from a group consisting of a first biodegradable plastic, a first biopolymer, and a first natural polymer,
• the first biodegradable plastic is at least one selected from a group consisting of (i) poly(glycolic acid), polyvinyl alcohol, polyglactin, polyethylene carbonate, and degradable polyurethane, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these,
• the first biopolymer is at least one selected from a group consisting of (i) collagen, fibrin, alginic acid, and hyaluronic acid, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these, and
• the first natural polymer is at least one selected from a group consisting of (i) chitosan, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these.

31:

• The porous body according to claim 18, wherein
• the porous body has a tube shape,
• the first surface is a inner cavity surface of the porous body, and
• the second surface is outer cavity surface of the porous body.

36:

• The porous body according to claim 19, wherein
• the first polymer material comprises at least one substance selected from a group consisting of a first biodegradable plastic, a first biopolymer, and a first natural polymer,
• the first biodegradable plastic is at least one selected from a group consisting of (i) poly(glycolic acid), polyvinyl alcohol, polyglactin, polyethylene carbonate, and degradable polyurethane, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these,
• the first biopolymer is at least one selected from a group consisting of (i) collagen, fibrin, alginic acid, and hyaluronic acid, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these, and
• the first natural polymer is at least one selected from a group consisting of (i) chitosan, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these.

37:

• The porous body according to claim 20, wherein
• the first polymer material comprises at least one substance selected from a group consisting of a first biodegradable plastic, a first biopolymer, and a first natural polymer,
• the first biodegradable plastic is at least one selected from a group consisting of (i) poly(glycolic acid), polyvinyl alcohol, polyglactin, polyethylene carbonate, and degradable polyurethane, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these,
• the first biopolymer is at least one selected from a group consisting of (i) collagen, fibrin, alginic acid, and hyaluronic acid, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these, and
• the first natural polymer is at least one selected from a group consisting of (i) chitosan, and (ii) at least two copolymers of monomers constituting these, or a copolymer of at least one of the monomers constituting these and another monomer, and (iii) salts and derivatives of these.