Bactericidal/permeability increasing protein for use in a method of immunization, preferably as an adjuvant in a method of vaccination
AssigneeUniversitäT Regensburg
InventorsANDRÉ GESSNER, SIGRID BÜLOW
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Abstract
The present invention relates to bactericidal/permeability increasing protein (BPI) for use in a method of immunization of a patient, preferably as an adjuvant in a method of vaccination. The present invention also relates to a preparation comprising BPI for use in a method of immunization of a patient, and optionally an immunomodulatory agent. The present invention further relates to a process of producing a preparation including BPI for use in a method of immunization of a patient.
Claims20
A method of immunization of a patient, said method comprising administering to a patient in need of such immunization an effective amount of bactericidal/permeability increasing Protein (BPI).
14-15. (canceled)
A process for producing a pharmaceutical preparation comprising BPI, wherein said process comprises the steps:
- i) providing, in any order, BPI, at least one excipient, and optionally an antigen;
- and
- ii) mixing said BPI, said at least one excipient, and optionally said antigen, to provide a preparation comprising BPI for use in a method of immunization of a patient.
The method according to claim ii, wherein the method triggers the generation of T cells selected from Th1 cells, Th17 cells, Th22 cells, Tfh cells, regulatory T cells, γδ T cells, and cytotoxic T cells.
Dependencies are inferred from the claim text.