US 2021/0292383 A1 · ALLERGY ANTIGEN AND EPITOPE THEREOF

Abstract

The present invention provides novel antigens of an allergy to soybean, methods and kits for diagnosing an allergy to soybean, pharmaceutical compositions comprising such an antigen, soybeans or processed products of soybean in which such an antigen is eliminated, and a tester for determining the presence or absence of a soybean antigen in an object of interest. The present invention also relates to polypeptides comprising an epitope of an allergen, kits, compositions and methods for diagnosing an allergy, comprising such a polypeptide, pharmaceutical compositions comprising such a polypeptide, and food raw materials or edible processed products in which an antigen comprising such a polypeptide is eliminated or reduced, or the polypeptide is cleaved or removed. The present invention further relates to a tester for determining the presence or absence of an antigen in an object of interest.

A polypeptide specifically binding to an IgE antibody from an allergic patient, the polypeptide being any one of the following:

(1β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
650-660;
(2β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
661-692;
(4β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
717-731;
(5β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
732-738;
(6β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
739 and 740;
(7β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
741-744;
(9β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
745-749;
(11β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
751-754;
(12β) a polypeptide comprising the amino acid sequence of SEQ ID NO:
755;
(13β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
756-758;
(14β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
759-764;
(15β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
765 and 766;
(17β) a polypeptide comprising the amino acid sequence of SEQ ID NO:
767;
(18β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
750 and 768-775;
(19β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
776-787;
(25β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
814 and 815;
(26β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
816-819;
(27β) a polypeptide comprising the amino acid sequence of SEQ ID NO:
820;
(28β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
821-835;
(29β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
836-839;
(34β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
840-846;
(35β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
847-856;
(36β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
857-861;
(38β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
862-892;
(39β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
893-895;
(40β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
896-902;
(41β) a polypeptide comprising the amino acid sequence of SEQ ID NO:
903;
(42β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
904-906;
(45β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
910-912;
(46β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
913-915;
(47β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
916-918;
(48β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
919-922;
(50β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
924-927;
(51β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
928-930;
(52β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
931-938;
(53β) a polypeptide comprising the amino acid sequence of SEQ ID NO:
939;
(54β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
940-943;
and
(55β) a polypeptide comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
944-952.

74 more elements

Allergy antigen and epitope thereof

Life of this patent

Allergy antigen and epitope thereof

Life of this patent

Abstract

Claims20